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Effect of Solid Dispersions on the Dissolution of Ampicillin
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| dc.contributor.author | Krasnyuk I. | |
| dc.contributor.author | Beliatskaya A. | |
| dc.contributor.author | Stepanova O. | |
| dc.contributor.author | Korol L. | |
| dc.contributor.author | Valeeva A. | |
| dc.contributor.author | Grikh V. | |
| dc.contributor.author | Ovsyannikova L. | |
| dc.contributor.author | Kosheleva T. | |
| dc.date.accessioned | 2018-09-19T22:59:47Z | |
| dc.date.available | 2018-09-19T22:59:47Z | |
| dc.date.issued | 2017 | |
| dc.identifier.issn | 2191-1630 | |
| dc.identifier.uri | https://dspace.kpfu.ru/xmlui/handle/net/145889 | |
| dc.description.abstract | © 2016, Springer Science+Business Media New York.In this work, we studied water solubility of ampicillin trihydrate and its solid dispersions (SD) with polyethylene glycol-1500, polyvinylpyrrolidone-10000, and β-cyclodextrin. It was found that SD formation increases the solubility by a factor of 1.34–1.73 and the rate of ampicillin dissolution by a factor of 3.43–7.40. The results of complex physicochemical studies suggest that the improved release of ampicillin from SD is due to its micronization and solubilization by the polymer. | |
| dc.relation.ispartofseries | BioNanoScience | |
| dc.subject | Ampicillin trihydrate | |
| dc.subject | Polyethylene glycol-1500 (PEG) | |
| dc.subject | Polyvinylpyrrolidone-10000 (PVP) | |
| dc.subject | Solid dispersions | |
| dc.subject | Solubility | |
| dc.subject | β-Cyclodextrin | |
| dc.title | Effect of Solid Dispersions on the Dissolution of Ampicillin | |
| dc.type | Article | |
| dc.relation.ispartofseries-issue | 2 | |
| dc.relation.ispartofseries-volume | 7 | |
| dc.collection | Публикации сотрудников КФУ | |
| dc.relation.startpage | 340 | |
| dc.source.id | SCOPUS21911630-2017-7-2-SID85019103499 |
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Публикации сотрудников КФУ Scopus [24551]
Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.