Kazan Federal University Digital Repository

Recombinant Plasmid DNA Construct Encoding Combination of vegf165 and bmp2 cDNAs Stimulates Osteogenesis and Angiogenesis In Vitro

Show simple item record

dc.contributor.author Zhuravleva M.
dc.contributor.author Khaliullin M.
dc.contributor.author Masgutov R.
dc.contributor.author Deev R.
dc.contributor.author Rizvanov A.
dc.date.accessioned 2018-09-19T22:59:39Z
dc.date.available 2018-09-19T22:59:39Z
dc.date.issued 2017
dc.identifier.issn 2191-1630
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/145885
dc.description.abstract © 2016, Springer Science+Business Media New York.Though normally bone regenerates well, non-union, delayed union, or defective bone formation can occur. Since impaired healing is often caused by local trophic disorders, standard fracture management is often ineffective. Gene therapy is a promising field for bone engineering. We have created a recombinant plasmid construct encoding the genes for pro-angiogenic vascular endothelial growth factor 165A (VEGF165A) and pro-osteogenic bone morphogenetic protein 2 (BMP2) with kanamycin resistance (pBudKan-VEGF165A-BMP2). This plasmid has the potential for use in treatment of trauma and skeletal system disorders, especially in cases of low trophicity.
dc.relation.ispartofseries BioNanoScience
dc.subject Angiogenesis
dc.subject Bone morphogenetic protein 2 (BMP2)
dc.subject Osteogenesis
dc.subject Plasmid
dc.subject Vascular endothelial growth factor (VEGF165)
dc.title Recombinant Plasmid DNA Construct Encoding Combination of vegf165 and bmp2 cDNAs Stimulates Osteogenesis and Angiogenesis In Vitro
dc.type Article
dc.relation.ispartofseries-issue 2
dc.relation.ispartofseries-volume 7
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 288
dc.source.id SCOPUS21911630-2017-7-2-SID85019099077


Files in this item

This item appears in the following Collection(s)

  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics