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Hantavirus infection suppresses thrombospondin-1 expression in cultured endothelial cells in a strain-specific manner

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dc.contributor.author Khaiboullina S.
dc.contributor.author Morzunov S.
dc.contributor.author St. Jeor S.
dc.contributor.author Rizvanov A.
dc.contributor.author Lombardi V.
dc.date.accessioned 2018-09-19T22:51:12Z
dc.date.available 2018-09-19T22:51:12Z
dc.date.issued 2016
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/145631
dc.description.abstract © 2016 Khaiboullina, Morzunov, St. Jeor, Rizvanov and Lombardi.Hantavirus infection is associated with two frequently fatal diseases in humans: Hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). The pathogenesis of hantavirus infection is complex and not fully understood; however, it is believed to involve virus-induced hyperinflammatory immune responses. Thrombospondin-1 (THBS1) is a large homotrimeric protein that plays a putative role in regulating blood homeostasis. Hyperresponsiveness to inflammatory stimuli has also been associated with defects in the THBS1 gene. Our data suggest that hantavirus infection of human umbilical cord vein endothelial cells (HUVEC) suppress the accumulation of THBS1 in the extracellular matrix. Additionally, this suppression is dependent on virus replication, implying a direct mechanism of action. Our data also imply that the pathogenic Andes and Hantaan strains inhibit THBS1 expression while the non-pathogenic Prospect Hill strain showed little inhibition. These observations suggest that a dysregulation of THBS1 may contribute to the pathogenesis of hantavirus infection.
dc.subject Andes
dc.subject Coagulation
dc.subject Hantaan
dc.subject HFRS
dc.subject HPS
dc.subject Prospect hill
dc.subject THBS1
dc.subject TSP1
dc.title Hantavirus infection suppresses thrombospondin-1 expression in cultured endothelial cells in a strain-specific manner
dc.type Article
dc.relation.ispartofseries-issue JUL
dc.relation.ispartofseries-volume 7
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS-2016-7--SID84983032242


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    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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