Kazan Federal University Digital Repository

Joint effect of the mycotoxins T-2 toxin, deoxynivalenol and zearalenone on the weaner pigs against a background of the infection load

Show simple item record

dc.contributor.author Semenov E.
dc.contributor.author Tremasov M.
dc.contributor.author Matrosova L.
dc.contributor.author Tarasova E.
dc.contributor.author Kryuchkova M.
dc.contributor.author Smolentsev S.
dc.contributor.author Korosteleva V.
dc.date.accessioned 2018-09-19T22:48:01Z
dc.date.available 2018-09-19T22:48:01Z
dc.date.issued 2016
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/145531
dc.description.abstract Currently, among more than 100 000 known species of fungi about 250 species produce mycotoxins, secondary metabolites which are dangerous to human and animal health. Most of these toxins are highly resistant to physical and chemical factors, and are not destroyed even after prolonged heating of feed contaminated with mycotoxins. The aim of the present study was to investigate the joint effects of T-2 toxin, zearalenone, deoxynivalenol and infectious agents on pigs. The study was conducted inthe Federal Center for Toxicological, Radiation and BiologicalSafety. Studies have shown that the jointdietary intake T-2 toxin at a dose of 70 mg/kg, zearalenoneat a dose of 50 mg/kg and deoxynivalenolat a dose of 1000 mg/kg for 30 days against a background of the simulated Clostridium infection load causes symptomatic mycotoxicosis which is accompanied by activation of lipoperoxidation, decrease in hematological, biochemical and immunological parameters: a reduction in the number of T and B lymphocytes, titers of specific protective antibodies and the development of pathological processes in the tissues and organs of weaner pigs, slow weight gain, increase in feed conversion ratio and the development of infectious disease, confirmed with laboratory tests. The result was different in the group of animals with the same infection load but without introducing mycotoxins into the animal diet. The findings provide strong evidence that chronic intake of fuzariotoxins even at the level of permissible concentrations against a background of infection load predisposes to infectious diseases.
dc.subject A mycotoxin combination of T-2 toxin
dc.subject Clostridium microorganisms
dc.subject Deoxynivalenol
dc.subject Immunity
dc.subject Zearalenone
dc.title Joint effect of the mycotoxins T-2 toxin, deoxynivalenol and zearalenone on the weaner pigs against a background of the infection load
dc.type Article
dc.relation.ispartofseries-issue 1
dc.relation.ispartofseries-volume 7
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 1860
dc.source.id SCOPUS-2016-7-1-SID84955301124


Files in this item

This item appears in the following Collection(s)

  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics