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Quantifying the area-at-risk of myocardial infarction in-vivo using arterial spin labeling cardiac magnetic resonance

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dc.contributor.author Dongworth R.
dc.contributor.author Campbell-Washburn A.
dc.contributor.author Cabrera-Fuentes H.
dc.contributor.author Bulluck H.
dc.contributor.author Roberts T.
dc.contributor.author Price A.
dc.contributor.author Hernández-Reséndiz S.
dc.contributor.author Ordidge R.
dc.contributor.author Thomas D.
dc.contributor.author Yellon D.
dc.contributor.author Lythgoe M.
dc.contributor.author Hausenloy D.
dc.date.accessioned 2018-09-19T22:33:10Z
dc.date.available 2018-09-19T22:33:10Z
dc.date.issued 2017
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/145306
dc.description.abstract © The Author(s) 2017.T2-weighted cardiovascular magnetic resonance (T2-CMR) of myocardial edema can quantify the area-at-risk (AAR) following acute myocardial infarction (AMI), and has been used to assess myocardial salvage by new cardioprotective therapies. However, some of these therapies may reduce edema, leading to an underestimation of the AAR by T2-CMR. Here, we investigated arterial spin labeling (ASL) perfusion CMR as a novel approach to quantify the AAR following AMI. Adult B6sv129-mice were subjected to in vivo left coronary artery ligation for 30 minutes followed by 72 hours reperfusion. T2-mapping was used to quantify the edema-based AAR (% of left ventricle) following ischemic preconditioning (IPC) or cyclosporin-A (CsA) treatment. In control animals, the AAR by T2-mapping corresponded to that delineated by histology. As expected, both IPC and CsA reduced MI size. However, IPC, but not CsA, also reduced myocardial edema leading to an underestimation of the AAR by T2-mapping. In contrast, regions of reduced myocardial perfusion delineated by cardiac ASL were able to delineate the AAR when compared to both T2-mapping and histology in control animals, and were not affected by either IPC or CsA. Therefore, ASL perfusion CMR may be an alternative method for quantifying the AAR following AMI, which unlike T2-mapping, is not affected by IPC.
dc.title Quantifying the area-at-risk of myocardial infarction in-vivo using arterial spin labeling cardiac magnetic resonance
dc.type Article
dc.relation.ispartofseries-issue 1
dc.relation.ispartofseries-volume 7
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS-2017-7-1-SID85019550802

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  • Публикации сотрудников КФУ Scopus [22633]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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