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dc.contributor.author | Kilinc E. | |
dc.contributor.author | Guerrero-Toro C. | |
dc.contributor.author | Zakharov A. | |
dc.contributor.author | Vitale C. | |
dc.contributor.author | Gubert-Olive M. | |
dc.contributor.author | Koroleva K. | |
dc.contributor.author | Timonina A. | |
dc.contributor.author | Luz L. | |
dc.contributor.author | Shelukhina I. | |
dc.contributor.author | Giniatullina R. | |
dc.contributor.author | Tore F. | |
dc.contributor.author | Safronov B. | |
dc.contributor.author | Giniatullin R. | |
dc.date.accessioned | 2018-09-19T22:03:46Z | |
dc.date.available | 2018-09-19T22:03:46Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0028-3908 | |
dc.identifier.uri | https://dspace.kpfu.ru/xmlui/handle/net/144645 | |
dc.description.abstract | © 2016 Elsevier LtdSerotonergic mechanisms play a central role in migraine pathology. However, the region-specific effects of serotonin (5-HT) mediated via multiple types of receptors in the nociceptive system are poorly understood. Using extracellular and patch-clamp recordings, we studied the action of 5-HT on the excitability of peripheral and central terminals of trigeminal afferents. 5-HT evoked long-lasting TTX-sensitive firing in the peripheral terminals of meningeal afferents, the origin site of migraine pain. Cluster analysis revealed that in majority of nociceptive fibers 5-HT induced either transient or persistent spiking activity with prevailing delta and theta rhythms. The 5-HT3-receptor antagonist MDL-72222 or 5-HT1B/D-receptor antagonist GR127935 largely reduced, but their combination completely prevented the excitatory pro-nociceptive action of 5-HT. The 5-HT3 agonist mCPBG activated spikes in MDL-72222-dependent manner but the 5HT-1 receptor agonist sumatriptan did not affect the nociceptive firing. 5-HT also triggered peripheral CGRP release in meninges, which was blocked by MDL-72222.5-HT evoked fast membrane currents and Ca2+ transients in a fraction of trigeminal neurons. Immunohistochemistry showed expression of 5-HT3A receptors in fibers innervating meninges. Endogenous release of 5-HT from degranulated mast cells increased nociceptive firing. Low pH but not histamine strongly activated firing. 5-HT reduced monosynaptic inputs from trigeminal Aδ- and C-afferents to the upper cervical lamina I neurons and this effect was blocked by MDL-72222. Consistent with central inhibitory effect, 5-HT reduced CGRP release in the brainstem slices. In conclusion, 5-HT evokes powerful pro-nociceptive peripheral and anti-nociceptive central effects in trigeminal system transmitting migraine pain. | |
dc.relation.ispartofseries | Neuropharmacology | |
dc.subject | 5-HT3 receptor | |
dc.subject | Migraine | |
dc.subject | Serotonin | |
dc.subject | Spike | |
dc.subject | Trigeminal nerve | |
dc.title | Serotonergic mechanisms of trigeminal meningeal nociception: Implications for migraine pain | |
dc.type | Article | |
dc.relation.ispartofseries-volume | 116 | |
dc.collection | Публикации сотрудников КФУ | |
dc.relation.startpage | 160 | |
dc.source.id | SCOPUS00283908-2017-116-SID85008312080 |