dc.contributor.author |
Tatarinov D. |
|
dc.contributor.author |
Kuznetsov D. |
|
dc.contributor.author |
Voloshina A. |
|
dc.contributor.author |
Lyubina A. |
|
dc.contributor.author |
Strobykina A. |
|
dc.contributor.author |
Mukhitova F. |
|
dc.contributor.author |
Polyancev F. |
|
dc.contributor.author |
Mironov V. |
|
dc.date.accessioned |
2018-09-19T22:00:04Z |
|
dc.date.available |
2018-09-19T22:00:04Z |
|
dc.date.issued |
2016 |
|
dc.identifier.issn |
0040-4020 |
|
dc.identifier.uri |
https://dspace.kpfu.ru/xmlui/handle/net/144573 |
|
dc.description.abstract |
© 2016 Elsevier LtdA new two-step synthesis of phosphonium salts from phosphine oxides using Grignard reagents is reported. This approach involves a cyclization of Z-dialkyl-(diaryl)[2-(5-chloro-2-hydroxyphenyl)-2-phenylvinyl]phosphine oxides under the action of sulfinyl chloride with the formation of 2,2-dialkyl(diaryl)-6-chloro-4-phenyl-2H-1,2-benzoxaphosphinin-2-ium chlorides followed by ring opening under the action of organomagnesium compounds. The method was successfully applied to prepare a series of a new phosphonium salts bearing phenolic moiety with a wide range of substituents at phosphorus atom. Synthesized phosphonium salts shows high antibacterial and antifungal in vitro activity and low toxicity towards human red blood cell. |
|
dc.relation.ispartofseries |
Tetrahedron |
|
dc.subject |
Cyclization |
|
dc.subject |
Grignard reagents |
|
dc.subject |
Phosphine oxides |
|
dc.subject |
Phosphonium salts |
|
dc.subject |
Quasiphosphonium salts |
|
dc.subject |
Ring opening |
|
dc.title |
Synthesis of 2-(2-hydroxyaryl)alkenylphosphonium salts from phosphine oxides via ring-closing ring-opening approach and their antimicrobial evaluation |
|
dc.type |
Article |
|
dc.relation.ispartofseries-issue |
51 |
|
dc.relation.ispartofseries-volume |
72 |
|
dc.collection |
Публикации сотрудников КФУ |
|
dc.relation.startpage |
8493 |
|
dc.source.id |
SCOPUS00404020-2016-72-51-SID84996497326 |
|