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Development of neuropeptide Y-mediated heart innervation in rats

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dc.contributor.author Masliukov P.
dc.contributor.author Moiseev K.
dc.contributor.author Emanuilov A.
dc.contributor.author Anikina T.
dc.contributor.author Zverev A.
dc.contributor.author Nozdrachev A.
dc.date.accessioned 2018-09-19T21:53:46Z
dc.date.available 2018-09-19T21:53:46Z
dc.date.issued 2016
dc.identifier.issn 0143-4179
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/144459
dc.description.abstract © 2015 Elsevier Ltd. Neuropeptide Y (NPY) playsa trophic role in the nervous and vascular systems and incardiac hypertrophy. However, there i s no report concerning the expression of NPY and its receptors in the heart during postnatal development. In the current study, immunohistochemistry and Western blot analysis was used to label NPY, and Y1R, Y2R, and Y5R receptors in the heart tissue and intramural cardiac ganglia from rats of different ages (newborn, 10 days old, 20 days old, 30 days old, 60 days old, 1 year old, and 2 years old). The obtained data suggest age-dependent changes of NPY-mediated heart innervation. The density of NPYimmunoreactive (IR) fibers was the least in newborn animals and increased in t h e first 20 days of life. In t he atria of newborn and 10-day-old rats, NPY-IR fibers were more abundant compared with t h e ventricles. The vast majority of NPY-IR fibers also contained tyrosine hydroxylase, a key enzyme in catecholamine synthesis. The expression of Y1R increased between 10 and 20 days oflife. Faint Y2R immunoreactivity was observed in the atria and ventricles of 20-day-old and older rats. In contrast, the highest level of the expression of Y5R was found in newborn pups comparing with more adult rats. All intramural ganglionic neurons were also Y1R-IR and Y5R-IR and Y2R-negative in all studied animals. Thus, the increasing of density of NPY-containing nerve fibers accompanies changes in relation of different subtypes of NPY receptors in the heart during development.
dc.relation.ispartofseries Neuropeptides
dc.subject Autonomic nervous system
dc.subject Development
dc.subject Heart innervation
dc.subject Immunohistochemistry
dc.subject Intramural ganglia
dc.subject Neuropeptide Y
dc.subject Receptors
dc.subject Western blot analysis
dc.title Development of neuropeptide Y-mediated heart innervation in rats
dc.type Article
dc.relation.ispartofseries-volume 55
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 47
dc.source.id SCOPUS01434179-2016-55-SID84957850661


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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