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dc.contributor.author | Gerasimov A. | |
dc.contributor.author | Varfolomeev M. | |
dc.contributor.author | Ziganshin M. | |
dc.contributor.author | Gorbatchuk V. | |
dc.contributor.author | Rakipov I. | |
dc.contributor.author | Klimovitskii A. | |
dc.contributor.author | Usmanova L. | |
dc.date.accessioned | 2018-09-19T21:52:59Z | |
dc.date.available | 2018-09-19T21:52:59Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0110-5558 | |
dc.identifier.uri | https://dspace.kpfu.ru/xmlui/handle/net/144444 | |
dc.description.abstract | © 2016 Journal of Advanced Pharmaceutical Technology and Research. In this work enthalpies of dissolution in water of polyethylene glycols (PEGs) having an average molecular weight of 1000 and 1400, Pluronic-F127, phenacetin as well as the composites prepared from them were measured using solution calorimetry at 298.15 K. Intermolecular interaction energies of polymer-phenacetin were calculated on the basis of an additive scheme. It was shown that for mixtures with high content of polymer (>90 wt%) Pluronic-F127 has the highest solubilizing effect, while for mixtures with (4-6):1 polymer: phenacetin ratio the best solubilizing agent is PEG-1400. Infrared-spectra showed a decrease of the number of self-associated molecules of phenacetin with increasing of polymer content in the composites. The obtained results enabled us to identify the features of intermolecular interactions of polymers with a model hydrophobic drug and may be used for optimizing the conditions for preparing solid dispersions based on hydrophilic polymers. | |
dc.relation.ispartofseries | Journal of Advanced Pharmaceutical Technology and Research | |
dc.subject | Enthalpy of solution | |
dc.subject | molecular interaction | |
dc.subject | phenacetin | |
dc.subject | Pluronic-F127 | |
dc.subject | polyethylene glycol | |
dc.subject | solution calorimetry | |
dc.title | Thermodynamics of dissolution and infrared-spectroscopy of solid dispersions of phenacetin | |
dc.type | Article | |
dc.relation.ispartofseries-issue | 1 | |
dc.relation.ispartofseries-volume | 7 | |
dc.collection | Публикации сотрудников КФУ | |
dc.relation.startpage | 6 | |
dc.source.id | SCOPUS01105558-2016-7-1-SID84955250879 |