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The relative contribution of nmdars to excitatory postsynaptic currents is controlled by ca2+-induced inactivation

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dc.contributor.author Valiullina F.
dc.contributor.author Zakharova Y.
dc.contributor.author Mukhtarov M.
dc.contributor.author Draguhn A.
dc.contributor.author Burnashev N.
dc.contributor.author Rozov A.
dc.date.accessioned 2018-09-19T21:31:44Z
dc.date.available 2018-09-19T21:31:44Z
dc.date.issued 2016
dc.identifier.issn 1662-5102
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/144094
dc.description.abstract © 2016 Valiullina, Zakharova, Mukhtarov, Draguhn, Burnashev and Rozov. NMDA receptors (NMDARs) are important mediators of excitatory synaptic transmission and plasticity. A hallmark of these channels is their high permeability to Ca2+. At the same time, they are themselves inhibited by the elevation of intracellular Ca2+ concentration. It is unclear however, whether the Ca2+ entry associated with single NMDAR mediated synaptic events is sufficient to self-inhibit their activation. Such auto-regulation would have important effects on the dynamics of synaptic excitation in several central neuronal networks. Therefore, we studied NMDAR-mediated synaptic currents in mouse hippocampal CA1 pyramidal neurons. Postsynaptic responses to subthreshold Schaffer collateral stimulation depended strongly on the absence or presence of intracellular Ca2+ buffers. Loading of pyramidal cells with exogenous Ca2+ buffers increased the amplitude and decay time of NMDAR mediated EPSCs (EPSPs) and prolonged the time window for action potential (AP) generation. Our data indicate that the Ca2+ influx mediated by unitary synaptic events is sufficient to produce detectable self-inhibition of NMDARs even at a physiological Mg2+ concentration. Therefore, the contribution of NMDARs to synaptic excitation is strongly controlled by both previous synaptic activity as well as by the Ca2+ buffer capacity of postsynaptic neurons.
dc.relation.ispartofseries Frontiers in Cellular Neuroscience
dc.subject Action potentials
dc.subject Calcium
dc.subject Excitation
dc.subject Firing properties
dc.subject Modulation
dc.subject NMDA receptor
dc.title The relative contribution of nmdars to excitatory postsynaptic currents is controlled by ca2+-induced inactivation
dc.type Article
dc.relation.ispartofseries-issue JAN
dc.relation.ispartofseries-volume 10
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS16625102-2016-10-JAN-SID84957795052


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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