dc.contributor.author |
Zarebska A. |
|
dc.contributor.author |
Jastrzebski Z. |
|
dc.contributor.author |
Ahmetov I. |
|
dc.contributor.author |
Zmijewski P. |
|
dc.contributor.author |
Cieszczyk P. |
|
dc.contributor.author |
Leonska-Duniec A. |
|
dc.contributor.author |
Sawczuk M. |
|
dc.contributor.author |
Leznicka K. |
|
dc.contributor.author |
Trybek G. |
|
dc.contributor.author |
Semenova E. |
|
dc.contributor.author |
Maciejewska-Skrendo A. |
|
dc.date.accessioned |
2018-09-19T21:04:36Z |
|
dc.date.available |
2018-09-19T21:04:36Z |
|
dc.date.issued |
2017 |
|
dc.identifier.issn |
1094-8341 |
|
dc.identifier.uri |
https://dspace.kpfu.ru/xmlui/handle/net/143558 |
|
dc.description.abstract |
© 2017 the American Physiological Society.The GSTP1 gene encodes glutathione S-transferase P1, which is a member of the glutathione S-transferases (GSTs), a family of enzymes playing an important role in detoxification and in the antioxidant defense system. There is some evidence indicating that GSTP1 c.313A>G polymorphism may be beneficial for exercise performance. Therefore, we decided to verify the association between the frequency of GSTP1 c.313A>G variants, physical performance, and athletes’ status in two cohorts: in a group of Russian athletes (n = 507) and in an independent population of Polish athletes (n = 510) in a replication study. The initial association study conducted with the Russian athletes revealed that the frequency of the minor G allele was significantly higher in all athletes than in controls; that was confirmed in the replication study of Polish athletes. In the combined cohort, the differences between athletes (n = 1017) and controls (n = 1246) were even more pronounced (32.7 vs 25.0%, P < 0.0001). Our findings emphasize that the G allele of the GSTP1 gene c.313A>G single nucleotide polymorphism is associated with improved endurance performance. These observations could support the hypothesis that the GSTP1 G allele may improve exercise performance by better elimination of exercise-induced ROS. |
|
dc.relation.ispartofseries |
Physiological Genomics |
|
dc.subject |
Athletes |
|
dc.subject |
Exercise performance |
|
dc.subject |
Gene frequency/genetics |
|
dc.subject |
Glutathione s-transferase |
|
dc.subject |
Muscle |
|
dc.subject |
Skeletal/metabolism |
|
dc.title |
GSTP1 c.313A>G polymorphism in Russian and Polish athletes |
|
dc.type |
Article |
|
dc.relation.ispartofseries-issue |
3 |
|
dc.relation.ispartofseries-volume |
49 |
|
dc.collection |
Публикации сотрудников КФУ |
|
dc.relation.startpage |
127 |
|
dc.source.id |
SCOPUS10948341-2017-49-3-SID85014727768 |
|