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Specifics of self-organization and properties of highly dilute aqueous solutions of polyoxidonium

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dc.contributor.author Ryzhkina I.
dc.contributor.author Sergeeva S.
dc.contributor.author Safiullin R.
dc.contributor.author Ryzhkin S.
dc.contributor.author Margulis A.
dc.contributor.author Murtazina L.
dc.contributor.author Timosheva A.
dc.contributor.author Chernova A.
dc.contributor.author Kadirov M.
dc.contributor.author Konovalov A.
dc.date.accessioned 2018-09-19T20:57:14Z
dc.date.available 2018-09-19T20:57:14Z
dc.date.issued 2016
dc.identifier.issn 1066-5285
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/143463
dc.description.abstract © 2016, Springer Science+Business Media New York.Using a combination of physicochemical methods (dynamic and electrophoretic light scattering (DLS and ELS, respectively), nanoparticle tracking analysis, atomic force and transmission electron microscopy (AFM and TEM, respectively), UV spectroscopy, conductometry, pH-metry, dielcometry), it was found that dilute solutions of a multicomponent drug immunomodulator polyoxidonium (PO) are nanoheterogeneous disperse systems, with their disperse phase undergoing considerable restructurings when diluting the solution in the range of calculated concentrations from 1∙10–1 to 1∙10–16 mg mL–1, which is reflected in the non-monotonous concentration dependencies of specific electroconductivity, dielectric permittivity, and pH of the solutions. Using ELS, AFM, TEM, and UV spectroscopy methods, it was found that the disperse phase with a size of hundreds of nanometers which forms at concentrations of ≤1∙10–5 mg mL–1, contains organized water structures substantiating the negative values of ζ-potential, which vary non-monotonously from–5 to–16 mV. Radioprotective properties of dilute solutions of PO (1∙10–1 and 1∙10–9 mg mL–1) were demonstrated for the first time when exposing the test mutant bacterial strain Salmonella typhimurium TA 100 (Ames test) to X-ray radiation in a dose of 7.50 mGy used for medical diagnostics.
dc.relation.ispartofseries Russian Chemical Bulletin
dc.subject aqueous nanoassociates
dc.subject dilute solutions
dc.subject disperse system
dc.subject multicomponent drug immunomodulator polyoxidonium
dc.subject radio-protective properties
dc.subject self-organization
dc.subject supramolecular domains
dc.title Specifics of self-organization and properties of highly dilute aqueous solutions of polyoxidonium
dc.type Article
dc.relation.ispartofseries-issue 6
dc.relation.ispartofseries-volume 65
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 1505
dc.source.id SCOPUS10665285-2016-65-6-SID85013419018


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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