dc.contributor.author |
Shrestha A. |
|
dc.contributor.author |
Mukhametshina R. |
|
dc.contributor.author |
Taghizadeh S. |
|
dc.contributor.author |
Vásquez-Pacheco E. |
|
dc.contributor.author |
Cabrera-Fuentes H. |
|
dc.contributor.author |
Rizvanov A. |
|
dc.contributor.author |
Mari B. |
|
dc.contributor.author |
Carraro G. |
|
dc.contributor.author |
Bellusci S. |
|
dc.date.accessioned |
2018-09-19T20:49:41Z |
|
dc.date.available |
2018-09-19T20:49:41Z |
|
dc.date.issued |
2017 |
|
dc.identifier.issn |
1058-8388 |
|
dc.identifier.uri |
https://dspace.kpfu.ru/xmlui/handle/net/143314 |
|
dc.description.abstract |
© 2016 Wiley Periodicals, Inc.Over the past decade, microRNA-142 (miR-142) is emerging as a major regulator of cell fate decision in the hematopoietic system. However, miR-142 is expressed in many other tissues, and recent evidence suggests that it may play a more pleiotropic role during embryonic development. In addition, miR-142 has been shown to play important functions in disease. miR-142 displays a functional role in cancer, virus infection, inflammation, and immune tolerance. Both a guide strand (miR-142-3p) and passenger strand (miR-142-5p) are generated from the miR-142 hairpin. miR-142-3p and -5p display overlapping but also independent target genes. Loss of function mouse models (genetrap, global knock out [KO], and conditional KO) have been reported and support the important role of miR-142 in different biological processes. This review will summarize the abundant literature already available for miR-142 and will lay the foundation for future works on this important microRNA. Developmental Dynamics 246:285–290, 2017. © 2016 Wiley Periodicals, Inc. |
|
dc.relation.ispartofseries |
Developmental Dynamics |
|
dc.subject |
development |
|
dc.subject |
disease |
|
dc.subject |
ERK |
|
dc.subject |
miR-142 |
|
dc.subject |
stem cells |
|
dc.subject |
WNT signaling |
|
dc.title |
MicroRNA-142 is a multifaceted regulator in organogenesis, homeostasis, and disease |
|
dc.type |
Review |
|
dc.relation.ispartofseries-issue |
4 |
|
dc.relation.ispartofseries-volume |
246 |
|
dc.collection |
Публикации сотрудников КФУ |
|
dc.relation.startpage |
285 |
|
dc.source.id |
SCOPUS10588388-2017-246-4-SID85014115309 |
|