New phosphorus dithioacids and their derivatives containing chiral centers and pharmacophoric groups

Abstract

© 2016 Taylor & Francis Group, LLC.New phosphorus dithioacids, their ammonium salts and S-silyl and plumbyl derivatives containing asymmetric carbon atoms and pharmacophoric groupswere obtained by the reactions of tetraphosphorus decasulfide and 1,3,2,4-dithiadiphosphetane-2,4-disulfides with chiral natural terpenyl alcohols, diols, carboxylic acid esters, amino acids and monosaccharides as well as synthetic chiral amines and 1-phenylethanol. The biological activity of the ammonium salts and S-esters of phosphorus dithioacids were studied.