Glycan multivalency effects toward albumin enable N-glycan-dependent tumor targeting

dc.contributor.author	Ogura A.
dc.contributor.author	Tahara T.
dc.contributor.author	Nozaki S.
dc.contributor.author	Onoe H.
dc.contributor.author	Kurbangalieva A.
dc.contributor.author	Watanabe Y.
dc.contributor.author	Tanaka K.
dc.date.accessioned	2018-09-19T20:43:36Z
dc.date.available	2018-09-19T20:43:36Z
dc.date.issued	2016
dc.identifier.issn	0960-894X
dc.identifier.uri	https://dspace.kpfu.ru/xmlui/handle/net/143184
dc.description.abstract	© 2016 Elsevier Ltd. All rights reserved.Multivalent interactions play an essential role in molecular recognition in living systems. These effects were employed to target tumor cells using albumin clusters bearing ∼10 molecules of asparagine-linked glycans (N-glycans). Noninvasive near-infrared fluorescence imaging clearly revealed A431 tumors implanted in BALB/cA-nu/nu mice after 1 h in an N-glycan structure-dependent manner, thereby demonstrating the efficient use of glycan multivalency effects for tumor targeting in vivo.
dc.relation.ispartofseries	Bioorganic and Medicinal Chemistry Letters
dc.subject	A431 tumor
dc.subject	In vivo molecular imaging
dc.subject	Multivalency effects
dc.subject	N-Glycan
dc.subject	α(2,3)-Disialoglycan
dc.title	Glycan multivalency effects toward albumin enable N-glycan-dependent tumor targeting
dc.type	Article
dc.relation.ispartofseries-issue	9
dc.relation.ispartofseries-volume	26
dc.collection	Публикации сотрудников КФУ
dc.relation.startpage	2251
dc.source.id	SCOPUS0960894X-2016-26-9-SID84962154863

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