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Co-polymers of oligolactic acid and tetrasubstituted thiacalix[4]arenes as a new material for electrochemical sensor development

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dc.contributor.author Gorbatchuk V.
dc.contributor.author Porfireva A.
dc.contributor.author Stepanova V.
dc.contributor.author Kuzin Y.
dc.contributor.author Evtugyn V.
dc.contributor.author Shamagsumova R.
dc.contributor.author Stoikov I.
dc.contributor.author Evtugyn G.
dc.date.accessioned 2018-09-19T20:39:45Z
dc.date.available 2018-09-19T20:39:45Z
dc.date.issued 2017
dc.identifier.issn 0925-4005
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/143101
dc.description.abstract © 2017New derivatives of oligolactic acid (OLA) have been obtained by cross-esterification with carboxylated thiacalix[4]arene derivatives in cone, paco and 1,3-alternate configurations. The products of the reaction characterized by NMR 1H, FTIR-ATR spectroscopy, MALDI-TOF mass spectroscopy and elemental analysis have been applied for surface modification of glassy carbon electrode (GCE). Electrochemical characterization with redox probes (ferricyanide ion and Methylene blue (MB)) showed predominant influence of electrostatic interactions influencing the flux of the charge carriers over the diffusion control. The role of a macrocycle moiety on the surface morphology and sensitivity toward measurement conditions has been established. The electrodes covered with new materials were applied as transducers in sensing specific DNA interactions and acetylcholinesterase (AChE) based hydrolysis of acetylthiocholine. This made it possible to distinguish factors affecting the DNA structure (MB intercalation, oxidative DNA damage, thermal denaturing) whereas immobilization of the AChE on the silver dendrites deposited in the inner volume of the polymers allowed recording the signal of thiocholine oxidation at extremely low working potential (0 mV vs. Ag/AgCl).
dc.relation.ispartofseries Sensors and Actuators, B: Chemical
dc.subject DNA biosensing
dc.subject Electrochemical sensor
dc.subject Oligolactic acid
dc.subject Thiacalix[4]arene
dc.subject Thiocholine oxidation
dc.title Co-polymers of oligolactic acid and tetrasubstituted thiacalix[4]arenes as a new material for electrochemical sensor development
dc.type Article
dc.relation.ispartofseries-volume 246
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 136
dc.source.id SCOPUS09254005-2017-246-SID85013076577


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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