Kazan Federal University Digital Repository

Interleukin-10 protects against atherosclerosis by modulating multiple atherogenic macrophage function

Show simple item record

dc.contributor.author Han X.
dc.contributor.author Boisvert W.
dc.date.accessioned 2018-09-19T20:31:52Z
dc.date.available 2018-09-19T20:31:52Z
dc.date.issued 2016
dc.identifier.issn 0340-6245
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/142986
dc.description.abstract © Schattauer 2015. Atherosclerosis is primarily a disorder of lipid metabolism, but there is also a prominent chronic inflammatory component that drives the atherosclerotic lesion progression in the artery wall. During hyperlipidaemic conditions, there is a rapid influx of circulating monocytes into the atherosclerosis-prone areas of the arterial intima. These infiltrated monocytes differentiate into macrophages and take up the atherogenic lipoproteins in the intima of the vessel wall that have been modified within the lesion environment. Interleukin (IL)-10 is a prototypic anti-inflammatory cytokine made primarily by the macrophages and Th2 subtype T lymphocytes. In terms of atherosclerosis its major roles include inhibition of macrophage activation as well as inhibition of matrix metalloproteinase, pro-inflammatory cytokines and cyclooxygenase- 2 expression in lipid-loaded and activated macrophage foam cells. Recent discoveries suggest another important role of IL-10 in atherosclerosis: its ability to alter lipid metabolism in macrophages. The current review will highlight the present knowledge on multiple ways in which IL-10 mediates atherosclerosis. As macrophages play a critical role in all stages of atherosclerosis, the review will concentrate on how IL-10 regulates the activities of macrophages that are especially important in the development of atherosclerosis.
dc.relation.ispartofseries Thrombosis and Haemostasis
dc.title Interleukin-10 protects against atherosclerosis by modulating multiple atherogenic macrophage function
dc.type Article
dc.relation.ispartofseries-issue 3
dc.relation.ispartofseries-volume 113
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 505
dc.source.id SCOPUS03406245-2016-113-3-SID84924185866


Files in this item

This item appears in the following Collection(s)

  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics