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Association of polymorphisms near the FOXC2 gene with the risk of varicose veins in ethnic Russians

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dc.contributor.author Shadrina A.
dc.contributor.author Smetanina M.
dc.contributor.author Sokolova E.
dc.contributor.author Sevost’ianova K.
dc.contributor.author Shevela A.
dc.contributor.author Demekhova M.
dc.contributor.author Shonov O.
dc.contributor.author Ilyukhin E.
dc.contributor.author Voronina E.
dc.contributor.author Zolotukhin I.
dc.contributor.author Kirienko A.
dc.contributor.author Filipenko M.
dc.date.accessioned 2018-09-19T20:27:19Z
dc.date.available 2018-09-19T20:27:19Z
dc.date.issued 2016
dc.identifier.issn 0268-3555
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/142917
dc.description.abstract © The Author(s) 2015.Objective: To investigate the association of polymorphisms located near the FOXC2 gene with the risk of varicose veins in ethnic Russians. Methods: Allele, genotype, and haplotype frequencies were determined in the sample of 474 patients with primary varicose veins and in the control group of 478 individuals without a history of chronic venous disease. Results: Polymorphisms rs7189489, rs4633732, and rs1035550 showed the association with the increased risk of varicose veins, but none of the observed associations remained significant after correction for multiple testing. Haplotype analysis revealed the association of haplotype rs7189489 C–rs4633732 T–rs34221221 C–rs1035550 C–rs34152738 T–rs12711457 G with the increased risk of varicose veins (OR = 2.67, P = 0.01). Conclusions: Our results provide evidence that the studied polymorphisms do not play a major role in susceptibility to varicose veins development in the Russian population.
dc.relation.ispartofseries Phlebology
dc.subject association
dc.subject FOXC2
dc.subject Russians
dc.subject single nucleotide polymorphism
dc.subject Varicose veins
dc.title Association of polymorphisms near the FOXC2 gene with the risk of varicose veins in ethnic Russians
dc.type Article
dc.relation.ispartofseries-issue 9
dc.relation.ispartofseries-volume 31
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 640
dc.source.id SCOPUS02683555-2016-31-9-SID84985896401


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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