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Comprehensive thermodynamic study of methylprednisolone

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dc.contributor.author Knyazev A.
dc.contributor.author Emel'yanenko V.
dc.contributor.author Smirnova N.
dc.contributor.author Zaitsau D.
dc.contributor.author Stepanova O.
dc.contributor.author Shipilova A.
dc.contributor.author Markin A.
dc.contributor.author Gusarova E.
dc.contributor.author Knyazeva S.
dc.contributor.author Verevkin S.
dc.date.accessioned 2018-09-19T20:14:53Z
dc.date.available 2018-09-19T20:14:53Z
dc.date.issued 2017
dc.identifier.issn 0021-9614
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/142734
dc.description.abstract © 2016 Elsevier LtdIn the present work the temperature dependence of heat capacity for methylprednisolone has been measured for the first time over the temperature range from 6 to 350 K using by precision adiabatic vacuum calorimetry. Based on the experimental data, the thermodynamic functions of the methylprednisolone, namely, the heat capacity, enthalpy H°(T) − H°(0), entropy S°(T) − S°(0) and Gibbs function G°(T) − H°(0) have been evaluated from the experimental values for the range from T → 0 to 350 K. Standard molar enthalpy of combustion (−11898.9 ± 6.7) kJ·mol−1 of the methylprednisolone was measured for the first time using high-precision combustion calorimeter. The standard molar enthalpy of formation in the crystalline state (−1045.8 ± 7.3) kJ·mol−1 of compound at 298.15 K was derived from the combustion experiments. The standard molar enthalpy of sublimation at 298.15 K (194.5 ± 2.2) kJ·mol−1 was measured by using the quartz-crystal microbalance (QCM). Using combination of the adiabatic and combustion calorimetry with the result from QCM, the thermodynamic functions of the methylprednisolone at T = 298.15 K and p = 0.1 MPa have been calculated.
dc.relation.ispartofseries Journal of Chemical Thermodynamics
dc.subject Combustion calorimetry
dc.subject Heat capacity
dc.subject Methylprednisolone
dc.subject Steroid hormone
dc.subject Thermodynamic functions
dc.subject Vapor pressure
dc.title Comprehensive thermodynamic study of methylprednisolone
dc.type Article
dc.relation.ispartofseries-volume 107
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 37
dc.source.id SCOPUS00219614-2017-107-SID85007227680


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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