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Emerging roles of the single EF-hand Ca<sup>2+</sup> sensor tescalcin in the regulation of gene expression, cell growth and differentiation

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dc.contributor.author Kolobynina K.
dc.contributor.author Solovyova V.
dc.contributor.author Levay K.
dc.contributor.author Rizvanov A.
dc.contributor.author Slepak V.
dc.date.accessioned 2018-09-19T20:14:10Z
dc.date.available 2018-09-19T20:14:10Z
dc.date.issued 2016
dc.identifier.issn 0021-9533
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/142720
dc.description.abstract © 2016. Published by The Company of Biologists Ltd.Tescalcin (TESC, also known as calcineurin-homologous protein 3, CHP3) is a 24-kDa EF-hand Ca2+-binding protein that has recently emerged as a regulator of cell differentiation and growth. The TESC gene has also been linked to human brain abnormalities, and high expression of tescalcin has been found in several cancers. The expression level of tescalcin changes dramatically during development and upon signal-induced cell differentiation. Recent studies have shown that tescalcin is not only subjected to up- or down-regulation, but also has an active role in pathways that drive cell growth and differentiation programs. At the molecular level, there is compelling experimental evidence showing that tescalcin can directly interact with and regulate the activities of the Na+/H+ exchanger NHE1, subunit 4 of the COP9 signalosome (CSN4) and protein kinase glycogen-synthase kinase 3 (GSK3). In hematopoetic precursor cells, tescalcin has been shown to couple activation of the extracellular signal-regulated kinase (ERK) cascade to the expression of transcription factors that control cell differentiation. The purpose of thisCommentary is to summarize recent efforts that have served to characterize the biochemical, genetic and physiological attributes of tescalcin, and its unique role in the regulation of various cellular functions.
dc.relation.ispartofseries Journal of Cell Science
dc.subject CHP3
dc.subject COP9
dc.subject Differentiation
dc.subject GSK3
dc.subject NHE1
dc.subject Tescalcin
dc.title Emerging roles of the single EF-hand Ca<sup>2+</sup> sensor tescalcin in the regulation of gene expression, cell growth and differentiation
dc.type Note
dc.relation.ispartofseries-issue 19
dc.relation.ispartofseries-volume 129
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 3533
dc.source.id SCOPUS00219533-2016-129-19-SID84995467457


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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