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Evaluation of the Hepatoprotective Effect of L-Ascorbate 1-(2-Hydroxyethyl)-4,6-Dimethyl-1,2-Dihydropyrimidine-2-One Upon Exposure to Carbon Tetrachloride
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| dc.contributor.author | Vyshtakalyuk A. | |
| dc.contributor.author | Nazarov N. | |
| dc.contributor.author | Zobov V. | |
| dc.contributor.author | Abdulkhakov S. | |
| dc.contributor.author | Minnekhanova O. | |
| dc.contributor.author | Semenov V. | |
| dc.contributor.author | Galyametdinova I. | |
| dc.contributor.author | Cherepnev G. | |
| dc.contributor.author | Reznik V. | |
| dc.date.accessioned | 2018-09-19T20:07:33Z | |
| dc.date.available | 2018-09-19T20:07:33Z | |
| dc.date.issued | 2017 | |
| dc.identifier.issn | 0007-4888 | |
| dc.identifier.uri | https://dspace.kpfu.ru/xmlui/handle/net/142590 | |
| dc.description.abstract | © 2017, Springer Science+Business Media New York.Hepatoprotective properties of a new pyrimidine derivative — L-ascorbate 1-(2-hydroxyethyl)-4,6-dimethyl-1,2-dihydropyrimidine-2-one, synthesized on the basis Xymedon, were assessed in white rats exposed to CCl4. The compound under study administered prior to exposure to CCl4 reduced the deviation of biochemical parameters from reference values and severity of structural and morphological changes in liver, when compared to the control. Hepatoprotective properties of the studied compound were more pronounced than those of Xymedon. | |
| dc.relation.ispartofseries | Bulletin of Experimental Biology and Medicine | |
| dc.subject | ascorbate | |
| dc.subject | CCl 4 | |
| dc.subject | hepatoprotectors | |
| dc.subject | pyrimidine derivatives | |
| dc.subject | toxic liver damage | |
| dc.title | Evaluation of the Hepatoprotective Effect of L-Ascorbate 1-(2-Hydroxyethyl)-4,6-Dimethyl-1,2-Dihydropyrimidine-2-One Upon Exposure to Carbon Tetrachloride | |
| dc.type | Article | |
| dc.relation.ispartofseries-issue | 3 | |
| dc.relation.ispartofseries-volume | 162 | |
| dc.collection | Публикации сотрудников КФУ | |
| dc.relation.startpage | 340 | |
| dc.source.id | SCOPUS00074888-2017-162-3-SID85009458562 |
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Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.