Selective Blockade of α<inf>2</inf>-Adrenoceptor Subtypes Modulates Contractility of Rat Myocardium

dc.contributor.author	Zefirov T.
dc.contributor.author	Khisamieva L.
dc.contributor.author	Ziyatdinova N.
dc.contributor.author	Zefirov A.
dc.date.accessioned	2018-09-19T20:07:31Z
dc.date.available	2018-09-19T20:07:31Z
dc.date.issued	2016
dc.identifier.issn	0007-4888
dc.identifier.uri	https://dspace.kpfu.ru/xmlui/handle/net/142589
dc.description.abstract	© 2016 Springer Science+Business Media New YorkThe study examined the dose-dependent effects of selective antagonists of α2A/D-, α2B-, and α2C- adrenoceptors applied in concentrations of 10—9-10—5 M on atrial and ventricular contractility of rat myocardium in vitro. Selective blockade of each α2-adrenoceptor subtype affected the contractile force of the atrial and ventricular strips. Various concentrations of α2A/D- and α2C-adrenoceptor antagonists produced positive inotropic effect on ventricular strips and negative effect on atrial strips. α2B-Adrenoceptor blocker in the majority of the tested concentrations produced a positive inotropic effect in both atria and ventricles.
dc.relation.ispartofseries	Bulletin of Experimental Biology and Medicine
dc.title	Selective Blockade of α<inf>2</inf>-Adrenoceptor Subtypes Modulates Contractility of Rat Myocardium
dc.type	Article in Press
dc.collection	Публикации сотрудников КФУ
dc.relation.startpage	1
dc.source.id	SCOPUS00074888-2016-SID85001090530

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Публикации сотрудников КФУ Scopus [24551]
Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.