Peculiar Aspects in Influence of α<inf>1</inf>-Adrenoceptor Stimulation on Isolated Rat Heart

dc.contributor.author	Zefirov T.
dc.contributor.author	Khabibrakhmanov I.
dc.contributor.author	Ziyatdinova N.
dc.contributor.author	Zefirov A.
dc.date.accessioned	2018-09-19T20:07:30Z
dc.date.available	2018-09-19T20:07:30Z
dc.date.issued	2016
dc.identifier.issn	0007-4888
dc.identifier.uri	https://dspace.kpfu.ru/xmlui/handle/net/142588
dc.description.abstract	© 2016 Springer Science+Business Media New YorkThe study examined the effect of α1-adrenoceptor stimulation with methoxamine on chronotropic function of isolated heart perfused ex vivo according to Langendorff and cardiac chronotropy in vivo. Stimulation of α1-adrenoceptors in isolated heart induced gradually developing bradycardia, which progressed during several minutes. Similar stimulation in vivo produced a short-term bradycardia probably terminated by the compensatory influences in the whole organism. Comparison of the data obtained in both experimental paradigms during α1-adrenoceptor stimulation revealed unidirectional changes in cardiac chronotropy characterized with time-related peculiarities.
dc.relation.ispartofseries	Bulletin of Experimental Biology and Medicine
dc.title	Peculiar Aspects in Influence of α<inf>1</inf>-Adrenoceptor Stimulation on Isolated Rat Heart
dc.type	Article in Press
dc.collection	Публикации сотрудников КФУ
dc.relation.startpage	1
dc.source.id	SCOPUS00074888-2016-SID84996562231

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