dc.contributor.author |
Zefirov T. |
|
dc.contributor.author |
Khisamieva L. |
|
dc.contributor.author |
Ziyatdinova N. |
|
dc.contributor.author |
Zefirov A. |
|
dc.date.accessioned |
2018-09-19T20:07:26Z |
|
dc.date.available |
2018-09-19T20:07:26Z |
|
dc.date.issued |
2016 |
|
dc.identifier.issn |
0007-4888 |
|
dc.identifier.uri |
https://dspace.kpfu.ru/xmlui/handle/net/142586 |
|
dc.description.abstract |
© 2016 Springer Science+Business Media New York.The study examined the dose-dependent effects of selective antagonists of α2A/D-, α2B-, and α2C-adrenoceptors applied in concentrations of 10-9-10-5 M on atrial and ventricular contractility of rat myocardium in vitro. Selective blockade of each α2-adrenoceptor subtype affected the contractile force of the atrial and ventricular strips. Various concentrations of α2A/D-and α2C-adrenoceptor antagonists produced positive inotropic effect on ventricular strips and negative effect on atrial strips. α2B-Adrenoceptor blocker in the majority of the tested concentrations produced a positive inotropic effect in both atria and ventricles. |
|
dc.relation.ispartofseries |
Bulletin of Experimental Biology and Medicine |
|
dc.subject |
Chronotropy |
|
dc.subject |
Heart |
|
dc.subject |
Rat |
|
dc.subject |
α -adrenoceptor 2 |
|
dc.title |
Selective blockade of α<inf>2</inf>-adrenoceptor subtypes modulates contractility of rat myocardium |
|
dc.type |
Article |
|
dc.relation.ispartofseries-issue |
2 |
|
dc.relation.ispartofseries-volume |
162 |
|
dc.collection |
Публикации сотрудников КФУ |
|
dc.relation.startpage |
177 |
|
dc.source.id |
SCOPUS00074888-2016-162-2-SID85011960817 |
|