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Effect of I<inf>Ca,L</inf> blockade on adrenergic stimulation in developing heart

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dc.contributor.author Zefirov T.
dc.contributor.author Kuptsova A.
dc.contributor.author Biktemirova R.
dc.contributor.author Ziyatdinova N.
dc.contributor.author Zefirov A.
dc.date.accessioned 2018-09-19T20:07:24Z
dc.date.available 2018-09-19T20:07:24Z
dc.date.issued 2016
dc.identifier.issn 0007-4888
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/142585
dc.description.abstract © 2016 Springer Science+Business Media New York.The effect of verapamil-induced blockade of L-type calcium ionic currents (ICa,L) on the action of non-selective adrenergic cardiac stimulation by norepinephrine was examined during different periods of early postnatal ontogeny. In 1-week-old rats, intravenous norepinephrine induced a short-term tachycardia both with and without preliminary injected verapamil. In 3-week-old rats, norepinephrine alone produced no chronotropic effect; in contrast, it induced a biphasic tachycardia in verapamil-treated rats. In 6- and 20-month-old rats, norepinephrine induced a short-term tachycardia, which could be prevented by verapamil. The age-related peculiarities of chronotropic action of non-selective adrenergic stimulation are indicative of the role of L-type calcium ionic channels in the development of sympathetic control over the heart.
dc.relation.ispartofseries Bulletin of Experimental Biology and Medicine
dc.subject Adrenoreceptors
dc.subject Chronotropy
dc.subject Heart
dc.subject L-type Ca channels 2+
dc.subject Ontogeny
dc.title Effect of I<inf>Ca,L</inf> blockade on adrenergic stimulation in developing heart
dc.type Article
dc.relation.ispartofseries-issue 6
dc.relation.ispartofseries-volume 161
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 746
dc.source.id SCOPUS00074888-2016-161-6-SID84992431071


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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