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Ketamine-Midazolam Anesthesia Induces Total Inhibition of Cortical Activity in the Brain of Newborn Rats

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dc.contributor.author Lebedeva Y.
dc.contributor.author Zakharova A.
dc.contributor.author Sitdikova G.
dc.contributor.author Zefirov A.
dc.contributor.author Khazipov R.
dc.date.accessioned 2018-09-19T20:07:20Z
dc.date.available 2018-09-19T20:07:20Z
dc.date.issued 2016
dc.identifier.issn 0007-4888
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/142583
dc.description.abstract © 2016, Springer Science+Business Media New York.The effects of general anesthetics ketamine and midazolam, the drugs that cause neuroapoptosis at the early stages of CNS development, on electrical activity of the somatosensory cortex in newborn rats were studied using extracellular recording of local field potentials and action potentials of cortical neurons. Combined administration of ketamine (40 mg/kg) and midazolam (9 mg/kg) induced surgical coma and almost completely suppressed early oscillatory patterns and neuronal firing. These effects persisted over 3 h after injection of the anesthetics. We concluded that general anesthesia induced by combined administration of ketamine and midazolam profoundly suppressed cortical activity in newborn rats, which can trigger neuroapoptosis in the developing brain.
dc.relation.ispartofseries Bulletin of Experimental Biology and Medicine
dc.subject anesthesia
dc.subject EEG
dc.subject newborn
dc.subject somatosensory cortex
dc.title Ketamine-Midazolam Anesthesia Induces Total Inhibition of Cortical Activity in the Brain of Newborn Rats
dc.type Article
dc.relation.ispartofseries-issue 1
dc.relation.ispartofseries-volume 161
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 15
dc.source.id SCOPUS00074888-2016-161-1-SID84979300826


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  • Публикации сотрудников КФУ Scopus [22633]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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