Электронный архив

Glatiramer Acetate and Nanny Proteins Restrict Access of the Multiple Sclerosis Autoantigen Myelin Basic Protein to the 26S Proteasome

Показать сокращенную информацию

dc.contributor.author Kuzina E.
dc.contributor.author Kudriaeva A.
dc.contributor.author Smirnov I.
dc.contributor.author Dubina M.
dc.contributor.author Gabibov A.
dc.contributor.author Belogurov A.
dc.date.accessioned 2018-09-18T20:49:02Z
dc.date.available 2018-09-18T20:49:02Z
dc.date.issued 2014
dc.identifier.issn 2314-6133
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/142462
dc.description.abstract © 2014 Ekaterina Kuzina et al. We recently showed that myelin basic protein (MBP) is hydrolyzed by 26S proteasome without ubiquitination. The previously suggested concept of charge-mediated interaction between MBP and the proteasome led us to attempt to compensate or mimic its positive charge to inhibit proteasomal degradation. We demonstrated that negatively charged actin and calmodulin (CaM), as well as basic histone H1.3, inhibit MBP hydrolysis by competing with the proteasome and MBP, respectively, for binding their counterpart. Interestingly, glatiramer acetate (GA), which is used to treat multiple sclerosis (MS) and is structurally similar to MBP, inhibits intracellular and in vitro proteasome-mediated MBP degradation. Therefore, the data reported in this study may be important for myelin biogenesis in both the normal state and pathophysiological conditions.
dc.relation.ispartofseries BioMed Research International
dc.title Glatiramer Acetate and Nanny Proteins Restrict Access of the Multiple Sclerosis Autoantigen Myelin Basic Protein to the 26S Proteasome
dc.type Article
dc.relation.ispartofseries-volume 2014
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS23146133-2014-2014-SID84931003441


Файлы в этом документе

Данный элемент включен в следующие коллекции

  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

Показать сокращенную информацию

Поиск в электронном архиве


Расширенный поиск

Просмотр

Моя учетная запись

Статистика