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Manganese in atherogenesis: Detection, origin, and a role

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dc.contributor.author Lozhkin A.
dc.contributor.author Biktagirov T.
dc.contributor.author Abdul'yanov V.
dc.contributor.author Gorshkov O.
dc.contributor.author Timonina E.
dc.contributor.author Mamin G.
dc.contributor.author Orlinskii S.
dc.contributor.author Silkin N.
dc.contributor.author Chernov V.
dc.contributor.author Khairullin R.
dc.contributor.author Salakhov M.
dc.contributor.author Ilinskaya O.
dc.date.accessioned 2018-09-18T20:33:32Z
dc.date.available 2018-09-18T20:33:32Z
dc.date.issued 2011
dc.identifier.issn 1990-7508
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/141134
dc.description.abstract The role of transition metal ions in atherogenesis is controversial; they may be involved in hydroxyl radical generation and can also catalyze the reactive oxygen species neutralization reaction as cofactors of antioxidant enzymes. Using EPR spectroscopy, we revealed that 70% of aorta specimens with atherosclerotic lesions possessed superoxide dismutase activity, 100% of the specimens initiated Fenton reaction and demonstrated the presence of manganese paramagnetic centers. The sodA gene encoding manganese-dependent bacterial superoxide dismutase was not found in the samples of atherosclerotic plaques by PCR using degenerate primers. The data obtained indicate prospects of manganese analysis as a marker element in the express diagnostics of atherosclerosis. © Pleiades Publishing, Ltd., 2011.
dc.relation.ispartofseries Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry
dc.subject Atherosclerosis
dc.subject Manganese
dc.subject SodA gene
dc.subject Superoxide dismutase
dc.title Manganese in atherogenesis: Detection, origin, and a role
dc.type Article
dc.relation.ispartofseries-issue 2
dc.relation.ispartofseries-volume 5
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 158
dc.source.id SCOPUS19907508-2011-5-2-SID80455141490


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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