Impact and intracellular localization of antibodies to DNA in MDCK cells

dc.contributor.author	Ivanova V.
dc.contributor.author	Nevzorova T.
dc.date.accessioned	2018-09-18T20:33:29Z
dc.date.available	2018-09-18T20:33:29Z
dc.date.issued	2013
dc.identifier.issn	1990-519X
dc.identifier.uri	https://dspace.kpfu.ru/xmlui/handle/net/141125
dc.description.abstract	A study was performed with liquid chromatography of highly purified antibodies to DNA of IgG from blood serum of healthy donors-SLE or RA patients and their clinically healthy relatives. It was shown that, depending on the pathology, these antibodies were distinguished by DNA-hydrolyzing activity. These antibodies were incubated with MDCK cells. It was found that they were mostly localized in the vicinity of the nucleus and affected the cellular morphology, number of viable cells, and chromatin of MDCK cells differently. The biological role of antibodies to DNA is discussed. © 2013 Pleiades Publishing, Ltd.
dc.relation.ispartofseries	Cell and Tissue Biology
dc.subject	antibodies to DNA
dc.subject	healthy relatives
dc.subject	MDCK
dc.subject	rheumatoid arthritis
dc.subject	systemic lupus erythematosus
dc.title	Impact and intracellular localization of antibodies to DNA in MDCK cells
dc.type	Article
dc.relation.ispartofseries-issue	3
dc.relation.ispartofseries-volume	7
dc.collection	Публикации сотрудников КФУ
dc.relation.startpage	271
dc.source.id	SCOPUS1990519X-2013-7-3-SID84878802160

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Публикации сотрудников КФУ Scopus [24551]
Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.