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Inhibition of phagocytic function of macrophages in vitro by dimer RNase of Bacillus intermedius

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dc.contributor.author Kalacheva N.
dc.contributor.author Konovalova O.
dc.contributor.author Nalimov D.
dc.contributor.author Salakhov M.
dc.contributor.author Il'nskaya O.
dc.contributor.author Kurinenko B.
dc.date.accessioned 2018-09-18T20:33:28Z
dc.date.available 2018-09-18T20:33:28Z
dc.date.issued 2008
dc.identifier.issn 1990-519X
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/141123
dc.description.abstract The interactions between rat peritoneal macrophage and Bacillus intermedius dimer RNase cross linked by dimethylsuberimidate was investigated in vitro. It has been found that dimer in the form of RNase at concentrations of 0.5-40μg/ml decreases the phagocytic function of macrophages. This is manifested as an inhibition of phagocytosis and suppression of the fusion of phagosomes with lysosomes in macrophages. Using atomic force microscopy, it is shown that the dimer RNase changes the surface structure of the cytoplasmic membrane more strongly than the monomer. The association between modifications of properties of the membrane and inhibition of the macrophage phagocytic function is discussed. © MAIK Nauka 2008.
dc.relation.ispartofseries Cell and Tissue Biology
dc.subject Bacillus intermedius RNase
dc.subject Cytoplasmic membrane
dc.subject Peritoneal macrophage
dc.subject Phagocytic function
dc.subject RNase dimer
dc.title Inhibition of phagocytic function of macrophages in vitro by dimer RNase of Bacillus intermedius
dc.type Article
dc.relation.ispartofseries-issue 4
dc.relation.ispartofseries-volume 2
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 411
dc.source.id SCOPUS1990519X-2008-2-4-SID51049092993


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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