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Electrophysiological mapping of rat sensorimotor lumbosacral spinal networks after complete paralysis

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dc.contributor.author Gad P.
dc.contributor.author Roy R.
dc.contributor.author Choe J.
dc.contributor.author Zhong H.
dc.contributor.author Nandra M.
dc.contributor.author Tai Y.
dc.contributor.author Gerasimenko Y.
dc.contributor.author Edgerton V.
dc.date.accessioned 2018-09-18T20:32:33Z
dc.date.available 2018-09-18T20:32:33Z
dc.date.issued 2015
dc.identifier.issn 0079-6123
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/140963
dc.description.abstract © 2015 Elsevier B.V. Stimulation of the spinal cord has been shown to have great potential for improving function after motor deficits caused by injury or pathological conditions. Using a wide range of animal models, many studies have shown that stimulation applied to the neural networks intrinsic to the spinal cord can result in a dramatic improvement of motor ability, even allowing an animal to step and stand after a complete spinal cord transection. Clinical use of this technology, however, has been slow to develop due to the invasive nature of the implantation procedures and the difficulty of ascertaining specific sites of stimulation that would provide optimal amelioration of the motor deficits. Moreover, the development of tools available to control precise stimulation chronically via biocompatible electrodes has been limited. In this chapter, we outline the use of a multisite electrode array in the spinal rat model to identify and stimulate specific sites of the spinal cord to produce discrete motor behaviors in spinal rats. The results demonstrate that spinal rats can stand and step when the spinal cord is stimulated tonically via electrodes located at specific sites on the spinal cord. The quality of stepping and standing was dependent on the location of the electrodes on the spinal cord, the specific stimulation parameters, and the orientation of the cathode and anode. The spinal motor evoked potentials in selected muscles during standing and stepping are shown to be critical tools to study selective activation of interneuronal circuits via responses of varying latencies. The present results provide further evidence that the assessment of functional networks in the background of behaviorally relevant functional states is likely to be a physiological tool of considerable importance in developing strategies to facilitate recovery of motor function after a number of neuromotor disorders.
dc.relation.ispartofseries Progress in Brain Research
dc.subject Electric enabling motor control
dc.subject Electrode array
dc.subject Locomotion
dc.subject Neurorehabilitation
dc.subject Spinal cord epidural stimulation
dc.subject Spinal motor evoked potentials
dc.title Electrophysiological mapping of rat sensorimotor lumbosacral spinal networks after complete paralysis
dc.type Article
dc.relation.ispartofseries-volume 218
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 199
dc.source.id SCOPUS00796123-2015-218-SID84955389702


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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