dc.contributor.author |
Gaifullina R. |
|
dc.contributor.author |
Katina M. |
|
dc.contributor.author |
Abdulhakov S. |
|
dc.contributor.author |
Kasimova L. |
|
dc.contributor.author |
Abdulhakova A. |
|
dc.contributor.author |
Rizvanov A. |
|
dc.date.accessioned |
2018-09-18T20:30:33Z |
|
dc.date.available |
2018-09-18T20:30:33Z |
|
dc.date.issued |
2012 |
|
dc.identifier.issn |
1815-445X |
|
dc.identifier.uri |
https://dspace.kpfu.ru/xmlui/handle/net/140622 |
|
dc.description.abstract |
Atherosclerosis is one of the leading causes of disability and death worldwide. Liver plays a huge role in pathogenesis of atherogenic dislipidemia, development and progression of atherosclerotic lesions. We studied the effect of atherogenic diet on liver morphology in animal model of diet-induced atherosclerosis in mice Mus musculus C57BI6. This strain has a natural ability to develop atherosclerosis, while some other mouse stains has not. After 14 weeks on atherogenic diet a severe hepathomegaly (9% of body mass) and lobular structure deformation was found. We also observed signs of micro- and macrovesicular steatosis, cell apoptosis, fibrosis and inflammatory leukocyte infiltration. So, liver not only plays an important role in dislipidemia, but it is also a target-organ in lipid metabolism imbalance. |
|
dc.relation.ispartofseries |
Cellular Transplantation and Tissue Engineering |
|
dc.subject |
Apoptosis |
|
dc.subject |
Atherosclerosis |
|
dc.subject |
Dislipidemia |
|
dc.subject |
Fibrosis |
|
dc.subject |
Inflammation |
|
dc.subject |
Liver |
|
dc.subject |
Steatosis |
|
dc.title |
Liver pathomorphology of Mus musculus C57BL6 on atherogenic diet |
|
dc.type |
Article |
|
dc.relation.ispartofseries-issue |
3 |
|
dc.relation.ispartofseries-volume |
7 |
|
dc.collection |
Публикации сотрудников КФУ |
|
dc.relation.startpage |
37 |
|
dc.source.id |
SCOPUS1815445X-2012-7-3-SID84871843565 |
|