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Epigenetics in lung cancer diagnosis and therapy

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dc.contributor.author Mehta A.
dc.contributor.author Dobersch S.
dc.contributor.author Romero-Olmedo A.
dc.contributor.author Barreto G.
dc.date.accessioned 2018-09-18T20:30:07Z
dc.date.available 2018-09-18T20:30:07Z
dc.date.issued 2015
dc.identifier.issn 0167-7659
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/140548
dc.description.abstract © 2015, Springer Science+Business Media New York. Lung cancer is the leading cause of cancer-related deaths worldwide. The initiation and progression of lung cancer is the result of the interaction between permanent genetic and dynamic epigenetic alterations. DNA methylation is the best studied epigenetic mark in human cancers. Altered DNA methylation in cancer was identified in 1983. Within 30 years of this discovery, DNA methylation inhibitors are used clinically to treat a variety of cancers, highlighting the importance of the epigenetic basis of cancer. In addition, histone modifications, nucleosome remodeling, and micro RNA (miRNA)-mediated gene regulation are also fundamental to tumor genesis. Distinct chromatin alterations occur in all stages of lung cancer, including initiation, growth, and metastasis. Therefore, stage-specific epigenetic changes can be used as powerful and reliable tools for early diagnosis of lung cancer and to monitor patient prognosis. Moreover, since epigenetic changes are dynamic and reversible, chromatin modifiers are promising targets for the development of more effective therapeutic strategies against cancer. This review summarizes the chromatin alterations in lung cancer, focusing on the diagnostic and therapeutic approaches targeting epigenetic modifications that could help to reduce the high case-fatality rate of this dreadful disease.
dc.relation.ispartofseries Cancer and Metastasis Reviews
dc.subject Chromatin
dc.subject DNA methylation
dc.subject Early diagnosis
dc.subject Epigenetics
dc.subject Histone modifications
dc.subject Lung cancer
dc.subject Metastasis
dc.subject miRNA
dc.subject Treatment
dc.title Epigenetics in lung cancer diagnosis and therapy
dc.type Article
dc.relation.ispartofseries-issue 2
dc.relation.ispartofseries-volume 34
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 229
dc.source.id SCOPUS01677659-2015-34-2-SID84938419882


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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