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Locomotor responses and neuron excitability in conditions of haloperidol blockade of dopamine in invertebrates and vertebrates

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dc.contributor.author Zvezdochkina N.
dc.contributor.author Muranova L.
dc.contributor.author Andrianov V.
dc.contributor.author Arkhipova S.
dc.contributor.author Gainutdinov K.
dc.contributor.author Golubev A.
dc.contributor.author Pleshchinskii I.
dc.date.accessioned 2018-09-18T20:28:27Z
dc.date.available 2018-09-18T20:28:27Z
dc.date.issued 2006
dc.identifier.issn 0097-0549
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/140262
dc.description.abstract Levels of movement activity were used to identify two groups of rats: Those with high- and low-activity levels. Blockade of dopamine receptors with haloperidol led to suppression of locomotor activity in both groups of rats; in common snails, haloperidol decreased the rate of locomotion. The excitability of spinal centers in rats decreased 5 min after single i.v. injections, with gradual recovery seen by 30 min. Chronic administration of haloperidol suppressed post-tetanic potentiation of the H response in the gastrocnemius muscle of spinal rats. Prolonged use of haloperidol induced significant hyperpolarization of the membrane potential of command neurons in common snails and increased the action potential generation threshold. Selective pharmacological exclusion of the brain dopamine system was found to lead to decreases in the excitability of defined neurons in snails and the spinal motor centers in rats, also producing impairments in locomotor responses in these animals. © 2006 Springer Science+Business Media, Inc.
dc.relation.ispartofseries Neuroscience and Behavioral Physiology
dc.subject Dopamine
dc.subject Gastrocnemius muscle reflex H response
dc.subject Haloperidol
dc.subject Locomotor activity
dc.subject Membrane potential
dc.subject Neuron excitability
dc.subject Threshold potential
dc.title Locomotor responses and neuron excitability in conditions of haloperidol blockade of dopamine in invertebrates and vertebrates
dc.type Article
dc.relation.ispartofseries-issue 1
dc.relation.ispartofseries-volume 36
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 21
dc.source.id SCOPUS00970549-2006-36-1-SID31544480410


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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