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Inflammatory cytokines kinetics define the severity and phase of nephropathia epidemica

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dc.contributor.author Baigildina A.
dc.contributor.author Khaiboullina S.
dc.contributor.author Martynova E.
dc.contributor.author Anokhin V.
dc.contributor.author Lombardi V.
dc.contributor.author Rizvanov A.
dc.date.accessioned 2018-09-18T20:25:44Z
dc.date.available 2018-09-18T20:25:44Z
dc.date.issued 2015
dc.identifier.issn 1752-0363
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/139779
dc.description.abstract © 2014 Future Medicine Ltd. Aims: Nephropathia epidemica (NE) is a form of hemorrhagic fever with renal syndrome associated with the Puumala virus species of Hantavirus. The pathogenesis of NE is not well understood; therefore, investigating the inflammatory cytokine response to infection may provide useful knowledge in deciphering the pathophysiology of NE. Materials & methods: Using Luminex and ELISA, we analyzed the serum of 137 NE cases and 44 controls to investigate if serum cytokines associate with different clinical presentations. Results: Serum levels of TNF-α and IL-1β are associated with disease severity while upregulation of IL-6, CXCL10, CCL2 and CCL3 are associated with clinical presentation. Conclusion: Inflammatory cytokine kinetics associate with the severity and phase of NE. Our data support a role for inflammatory cytokines in the pathophysiology of NE.
dc.relation.ispartofseries Biomarkers in Medicine
dc.subject Cytokine
dc.subject Hantavirus
dc.subject HRFS
dc.subject Nephropathia epidemica
dc.subject Puumala virus
dc.title Inflammatory cytokines kinetics define the severity and phase of nephropathia epidemica
dc.type Article
dc.relation.ispartofseries-issue 2
dc.relation.ispartofseries-volume 9
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 99
dc.source.id SCOPUS17520363-2015-9-2-SID84923455541


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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