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Polyamine modification by acrolein exclusively produces 1,5-diazacyclooctanes: A previously unrecognized mechanism for acrolein-mediated oxidative stress

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dc.contributor.author Tsutsui A.
dc.contributor.author Imamaki R.
dc.contributor.author Kitazume S.
dc.contributor.author Hanashima S.
dc.contributor.author Yamaguchi Y.
dc.contributor.author Kaneda M.
dc.contributor.author Oishi S.
dc.contributor.author Fujii N.
dc.contributor.author Kurbangalieva A.
dc.contributor.author Taniguchi N.
dc.contributor.author Tanaka K.
dc.date.accessioned 2018-09-18T20:22:53Z
dc.date.available 2018-09-18T20:22:53Z
dc.date.issued 2014
dc.identifier.issn 1477-0520
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/139286
dc.description.abstract Acrolein, a toxic unsaturated aldehyde generated as a result of oxidative stress, readily reacts with a variety of nucleophilic biomolecules. Polyamines, which produced acrolein in the presence of amine oxidase, were then found to react with acrolein to produce 1,5-diazacyclooctane, a previously unrecognized but significant downstream product of oxidative stress. Although diazacyclooctane formation effectively neutralized acrolein toxicity, the diazacyclooctane hydrogel produced through a sequential diazacyclooctane polymerization reaction was highly cytotoxic. This study suggests that diazacyclooctane formation is involved in the mechanism underlying acrolein-mediated oxidative stress. © 2014 the Partner Organisations.
dc.relation.ispartofseries Organic and Biomolecular Chemistry
dc.title Polyamine modification by acrolein exclusively produces 1,5-diazacyclooctanes: A previously unrecognized mechanism for acrolein-mediated oxidative stress
dc.type Article
dc.relation.ispartofseries-issue 28
dc.relation.ispartofseries-volume 12
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 5151
dc.source.id SCOPUS14770520-2014-12-28-SID84903118251


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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