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Hydrogen bonding in Alzheimer's amyloid-β fibrils probed by 15N{17O} REAPDOR solid-state NMR spectroscopy

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dc.contributor.author Antzutkin O.
dc.contributor.author Iuga D.
dc.contributor.author Filippov A.
dc.contributor.author Kelly R.
dc.contributor.author Becker-Baldus J.
dc.contributor.author Brown S.
dc.contributor.author Dupree R.
dc.date.accessioned 2018-09-18T20:22:29Z
dc.date.available 2018-09-18T20:22:29Z
dc.date.issued 2012
dc.identifier.issn 1433-7851
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/139216
dc.description.abstract An exclusive label: 15N{17O} REAPDOR NMR was used to validate intermolecular C17O=H-15N hydrogen bonding in Ac-Aβ(16-22)-NH2 (see scheme) and Aβ(11-25) amyloid fibrils, which are associated with Alzheimer's disease, by selectively labeling them with 17O and 15N. This method was effective for confirming the structure of these fibrils, and could be useful for a number of other biological samples. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
dc.relation.ispartofseries Angewandte Chemie - International Edition
dc.subject 15N{17O} REAPDOR NMR
dc.subject amyloid-β fibrils
dc.subject hydrogen bonds
dc.subject NMR spectroscopy
dc.subject solid-state NMR
dc.title Hydrogen bonding in Alzheimer's amyloid-β fibrils probed by 15N{17O} REAPDOR solid-state NMR spectroscopy
dc.type Article
dc.relation.ispartofseries-issue 41
dc.relation.ispartofseries-volume 51
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 10289
dc.source.id SCOPUS14337851-2012-51-41-SID84867049078


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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