Hydrogen bonding in Alzheimer's amyloid-β fibrils probed by 15N{17O} REAPDOR solid-state NMR spectroscopy

dc.contributor.author	Antzutkin O.
dc.contributor.author	Iuga D.
dc.contributor.author	Filippov A.
dc.contributor.author	Kelly R.
dc.contributor.author	Becker-Baldus J.
dc.contributor.author	Brown S.
dc.contributor.author	Dupree R.
dc.date.accessioned	2018-09-18T20:22:29Z
dc.date.available	2018-09-18T20:22:29Z
dc.date.issued	2012
dc.identifier.issn	1433-7851
dc.identifier.uri	https://dspace.kpfu.ru/xmlui/handle/net/139216
dc.description.abstract	An exclusive label: 15N{17O} REAPDOR NMR was used to validate intermolecular C17O=H-15N hydrogen bonding in Ac-Aβ(16-22)-NH2 (see scheme) and Aβ(11-25) amyloid fibrils, which are associated with Alzheimer's disease, by selectively labeling them with 17O and 15N. This method was effective for confirming the structure of these fibrils, and could be useful for a number of other biological samples. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
dc.relation.ispartofseries	Angewandte Chemie - International Edition
dc.subject	15N{17O} REAPDOR NMR
dc.subject	amyloid-β fibrils
dc.subject	hydrogen bonds
dc.subject	NMR spectroscopy
dc.subject	solid-state NMR
dc.title	Hydrogen bonding in Alzheimer's amyloid-β fibrils probed by 15N{17O} REAPDOR solid-state NMR spectroscopy
dc.type	Article
dc.relation.ispartofseries-issue	41
dc.relation.ispartofseries-volume	51
dc.collection	Публикации сотрудников КФУ
dc.relation.startpage	10289
dc.source.id	SCOPUS14337851-2012-51-41-SID84867049078

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