dc.contributor.author |
Branco A. |
|
dc.contributor.author |
Moreira A. |
|
dc.contributor.author |
Cunha-Oliveira T. |
|
dc.contributor.author |
Couto R. |
|
dc.contributor.author |
Sardão V. |
|
dc.contributor.author |
Rizvanov A. |
|
dc.contributor.author |
Palotás A. |
|
dc.contributor.author |
Oliveira P. |
|
dc.date.accessioned |
2018-09-18T20:22:22Z |
|
dc.date.available |
2018-09-18T20:22:22Z |
|
dc.date.issued |
2014 |
|
dc.identifier.issn |
1389-4501 |
|
dc.identifier.uri |
https://dspace.kpfu.ru/xmlui/handle/net/139195 |
|
dc.description.abstract |
© 2014 Bentham Science Publishers. Neuro-hormonal regulation of cardiac function via cathecol-amines results in increased heart rate and contractility. A persistent adrenergic tone, however, is an insult to the heart, affecting its regular homeostasis, altering morphology and gene expression patterns, as well as inducing apoptosis of cardio-myocytes. At the same time as being the main oxygen consumers, mitochondria are also key to the energy production required for the heart to maintain its vital functions and to integrate a series of signaling pathways that define the life and death of the cell. As β-adrenergic receptors (β-AR) orchestrate multiple biochemical events that can either trigger or inhibit cell death, mitochondria can act as a referee in the entire process. In fact, β-AR subtypes β<inf>1</inf> and β<inf>2</inf> activate various down-stream pathways which differently modulate intracellular calcium levels and production of mitochondrial reactive oxygen species (ROS). The delicate balance between an adaptive (cardio-protective) response resulting in increased contractility and activation of survival pathways, vs. cell death caused by calcium and ROS-induced mitochondrial disruption, along with evidence of their clinical and potential therapeutic translations, are reviewed in this communication. |
|
dc.relation.ispartofseries |
Current Drug Targets |
|
dc.subject |
Apoptosis |
|
dc.subject |
Calcium |
|
dc.subject |
Cardio-myocyte |
|
dc.subject |
Mitochondria |
|
dc.subject |
Oxidative stress |
|
dc.subject |
β-adrenergic receptors |
|
dc.title |
β-adrenergic over-stimulation and cardio-myocyte apoptosis: Two receptors, one organelle, two fates? |
|
dc.type |
Article |
|
dc.relation.ispartofseries-issue |
10 |
|
dc.relation.ispartofseries-volume |
15 |
|
dc.collection |
Публикации сотрудников КФУ |
|
dc.relation.startpage |
956 |
|
dc.source.id |
SCOPUS13894501-2014-15-10-SID84925936688 |
|