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Coronary artery bypass surgery provokes alzheimer's disease-like changes in the cerebrospinal fluid

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dc.contributor.author Palotás A.
dc.contributor.author Reis H.
dc.contributor.author Bogáts G.
dc.contributor.author Babik B.
dc.contributor.author Racsmány M.
dc.contributor.author Engvau L.
dc.contributor.author Kecskeméti E.
dc.contributor.author Juhász A.
dc.contributor.author Vieira L.
dc.contributor.author Teixeira A.
dc.contributor.author Mukhamedyarov M.
dc.contributor.author Rizvanov A.
dc.contributor.author Yalvaç M.
dc.contributor.author Guimarêes M.
dc.contributor.author Ferreira C.
dc.contributor.author Zefirov A.
dc.contributor.author Kiyasov A.
dc.contributor.author Wang L.
dc.contributor.author Janka Z.
dc.contributor.author Kálmán J.
dc.date.accessioned 2018-09-18T20:22:14Z
dc.date.available 2018-09-18T20:22:14Z
dc.date.issued 2010
dc.identifier.issn 1387-2877
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/139172
dc.description.abstract Several biomarkers are used in confirming the diagnosis of cognitive disorders. This study evaluates whether the level of these markers after heart surgery correlates with the development of cognitive dysfunction, which is a frequent complication of cardiac interventions. Concentrations of amyloid-β peptide, tau, and S100β in the cerebro-spinal fluid were assessed, as well as cognitive functions were evaluated before and after coronary artery bypass grafting, utilizing immuno-assays and psychometric tests, respectively. A drastic rise in the level of S100β was observed one week after the surgery, a mark of a severe generalized cerebral injury. The level of amyloid-β peptide significantly decreased, whereas the concentration of tau markedly increased six months postoperatively. Gradual cognitive decline was also present. These findings clearly demonstrate post-surgical cognitive impairment associated with changes in biomarkers similar to that seen in Alzheimer's disease, suggesting a unifying pathognomic factor between the two disorders. A holistic approach to coronary heart disease and Alzheimer's-type dementia is proposed. © 2010 IOS Press and the authors. All rights reserved.
dc.relation.ispartofseries Journal of Alzheimer's Disease
dc.subject Alzheimer's disease
dc.subject amyloid-β peptide
dc.subject biomarker
dc.subject cardiac surgery
dc.subject cerebrospinal fluid
dc.subject cognitive function
dc.subject postoperative cognitive decline
dc.subject S100β
dc.subject tau
dc.title Coronary artery bypass surgery provokes alzheimer's disease-like changes in the cerebrospinal fluid
dc.type Article
dc.relation.ispartofseries-issue 4
dc.relation.ispartofseries-volume 21
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 1153
dc.source.id SCOPUS13872877-2010-21-4-SID78650491097


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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