Determination of captopril in pharmaceutical forms by stripping voltammetry

Abstract

A voltammetric procedure is developed for determining captopril in pharmaceuticals. It is based on the preliminary electrochemical accumulation of the captopril oxidation product on a platinum electrode in a 0.1 M HNO 3 solution at 1.2 V versus a saturated silver-silver chloride electrode. The reduction current of the oxidation product is a linear function of captopril concentration in the range from 1.2 × 10 -6 to 3.2 × 10 -4 M. The determination limit is 9.2 × 10 -7 M. The relative standard deviation is between 1 and 4%. © Pleiades Publishing, Inc., 2006.