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Electrochemical Biosensors Based on Native DNA and Nanosized Mediator for the Detection of Anthracycline Preparations

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dc.contributor.author Evtugyn G.
dc.contributor.author Porfireva A.
dc.contributor.author Stepanova V.
dc.contributor.author Budnikov H.
dc.date.accessioned 2018-09-18T20:13:26Z
dc.date.available 2018-09-18T20:13:26Z
dc.date.issued 2015
dc.identifier.issn 1040-0397
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/137711
dc.description.abstract © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. A novel electrochemical DNA-sensor based on glassy carbon electrode (GCE) modified with electropolymerized Neutral red (NR) and polycarboxylated thiacax[4]arene with covalently attached mediator and electrostatically adsorbed DNA was developed for sensitive detection of anthracycline preparations. Intercalation of doxorubicin, daunorubicin and idarubicin into DNA increases the charge transfer resistance and decreases the electron exchange resulted in decay of the cathodic peak of NR reduction. The DNA-sensor developed makes it possible to determine down to 0.05nM doxorubicin, o.1nM doxorubicin and 0.5nM idarubicin. The DNA-sensor was tested on detection of doxorubicin in pharmaceuticals and artificial blood plasma with 95-100% recovery.
dc.relation.ispartofseries Electroanalysis
dc.subject Anthracycline pharmaceuticals
dc.subject DNA sensor
dc.subject Electrochemical impedance
dc.subject Nanosized mediator
dc.subject Poly(Neutral red)
dc.title Electrochemical Biosensors Based on Native DNA and Nanosized Mediator for the Detection of Anthracycline Preparations
dc.type Article
dc.relation.ispartofseries-issue 3
dc.relation.ispartofseries-volume 27
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 629
dc.source.id SCOPUS10400397-2015-27-3-SID84924804665


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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