dc.contributor.author |
Ivanova V. |
|
dc.contributor.author |
Khaiboullina S. |
|
dc.contributor.author |
Cherenkova E. |
|
dc.contributor.author |
Martynova E. |
|
dc.contributor.author |
Nevzorova T. |
|
dc.contributor.author |
Kunst M. |
|
dc.contributor.author |
Sibgatullin T. |
|
dc.contributor.author |
Maksudova A. |
|
dc.contributor.author |
Oliveira P. |
|
dc.contributor.author |
Lombardi V. |
|
dc.contributor.author |
Palotás A. |
|
dc.contributor.author |
Rizvanov A. |
|
dc.date.accessioned |
2018-09-18T20:12:51Z |
|
dc.date.available |
2018-09-18T20:12:51Z |
|
dc.date.issued |
2014 |
|
dc.identifier.issn |
1015-8987 |
|
dc.identifier.uri |
https://dspace.kpfu.ru/xmlui/handle/net/137624 |
|
dc.description.abstract |
© 2015 S. Karger AG, Basel. Background: Circulating auto-reactive antibodies are hallmark features of auto-immune diseases, however little is known with respect to the specificity of such bio-markers. In the present study, we investigated the specificity of anti-nucleic acid antibodies in the blood of subjects with systemic lupus erythematosus (SLE) and healthy controls. Methods: Sera from 12 SLE cases and 8 controls were evaluated for immuno-reactivity to purified RNA, DNA and mitochondrial DNA (mtDNA) by enzyme-linked immuno-sorbent assay (ELISA). Results: As expected, immuno-reactivity to total nucleic acids was significantly higher in subjects with SLE when compared to healthy controls, however a clear distinction was observed among the various nucleic acid sub-types, with sera from SLE subjects displaying the greatest immuno-reactivity to RNA followed by mtDNA and then total DNA. Conclusion: The identification of auto-reactive antibodies can serve as highly sensitive biomarkers, although their specificity may not always allow diagnostic certainty. The knowledge that auto-antibodies in subjects with SLE display differential immuno-reactivity may help to improve existing diagnostics and may lead to a better understanding of the pathogenesis of auto-immune disorders. |
|
dc.relation.ispartofseries |
Cellular Physiology and Biochemistry |
|
dc.subject |
Auto-antibody |
|
dc.subject |
Auto-antigens |
|
dc.subject |
Auto-immune disease |
|
dc.subject |
Biomarker |
|
dc.subject |
Mitochondria |
|
dc.subject |
Nucleic acid |
|
dc.subject |
Systemic lupus erythematosus (SLE) |
|
dc.title |
Differential immuno-reactivity to genomic DNA, RNA and mitochondrial DNA is associated with auto-immunity |
|
dc.type |
Article |
|
dc.relation.ispartofseries-issue |
6 |
|
dc.relation.ispartofseries-volume |
34 |
|
dc.collection |
Публикации сотрудников КФУ |
|
dc.relation.startpage |
2200 |
|
dc.source.id |
SCOPUS10158987-2014-34-6-SID84920915026 |
|