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dc.contributor.author | Ivanova V. | |
dc.contributor.author | Khaiboullina S. | |
dc.contributor.author | Cherenkova E. | |
dc.contributor.author | Martynova E. | |
dc.contributor.author | Nevzorova T. | |
dc.contributor.author | Kunst M. | |
dc.contributor.author | Sibgatullin T. | |
dc.contributor.author | Maksudova A. | |
dc.contributor.author | Oliveira P. | |
dc.contributor.author | Lombardi V. | |
dc.contributor.author | Palotás A. | |
dc.contributor.author | Rizvanov A. | |
dc.date.accessioned | 2018-09-18T20:12:51Z | |
dc.date.available | 2018-09-18T20:12:51Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1015-8987 | |
dc.identifier.uri | https://dspace.kpfu.ru/xmlui/handle/net/137624 | |
dc.description.abstract | © 2015 S. Karger AG, Basel. Background: Circulating auto-reactive antibodies are hallmark features of auto-immune diseases, however little is known with respect to the specificity of such bio-markers. In the present study, we investigated the specificity of anti-nucleic acid antibodies in the blood of subjects with systemic lupus erythematosus (SLE) and healthy controls. Methods: Sera from 12 SLE cases and 8 controls were evaluated for immuno-reactivity to purified RNA, DNA and mitochondrial DNA (mtDNA) by enzyme-linked immuno-sorbent assay (ELISA). Results: As expected, immuno-reactivity to total nucleic acids was significantly higher in subjects with SLE when compared to healthy controls, however a clear distinction was observed among the various nucleic acid sub-types, with sera from SLE subjects displaying the greatest immuno-reactivity to RNA followed by mtDNA and then total DNA. Conclusion: The identification of auto-reactive antibodies can serve as highly sensitive biomarkers, although their specificity may not always allow diagnostic certainty. The knowledge that auto-antibodies in subjects with SLE display differential immuno-reactivity may help to improve existing diagnostics and may lead to a better understanding of the pathogenesis of auto-immune disorders. | |
dc.relation.ispartofseries | Cellular Physiology and Biochemistry | |
dc.subject | Auto-antibody | |
dc.subject | Auto-antigens | |
dc.subject | Auto-immune disease | |
dc.subject | Biomarker | |
dc.subject | Mitochondria | |
dc.subject | Nucleic acid | |
dc.subject | Systemic lupus erythematosus (SLE) | |
dc.title | Differential immuno-reactivity to genomic DNA, RNA and mitochondrial DNA is associated with auto-immunity | |
dc.type | Article | |
dc.relation.ispartofseries-issue | 6 | |
dc.relation.ispartofseries-volume | 34 | |
dc.collection | Публикации сотрудников КФУ | |
dc.relation.startpage | 2200 | |
dc.source.id | SCOPUS10158987-2014-34-6-SID84920915026 |