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Electrochemical approach for acute myocardial infarction diagnosis based on direct antibodies-free analysis of human blood plasma

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dc.contributor.author Suprun E.
dc.contributor.author Saveliev A.
dc.contributor.author Evtugyn G.
dc.contributor.author Lisitsa A.
dc.contributor.author Bulko T.
dc.contributor.author Shumyantseva V.
dc.contributor.author Archakov A.
dc.date.accessioned 2018-09-18T20:11:26Z
dc.date.available 2018-09-18T20:11:26Z
dc.date.issued 2012
dc.identifier.issn 0956-5663
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/137413
dc.description.abstract A novel direct antibodies-free electrochemical approach for acute myocardial infarction (AMI) diagnosis has been developed. For this purpose, a combination of the electrochemical assay of plasma samples with chemometrics was proposed. Screen printed carbon electrodes modified with didodecyldimethylammonium bromide were used for plasma charactrerization by cyclic (CV) and square wave voltammetry and square wave (SWV) voltammetry. It was shown that the cathodic peak in voltammograms at about -250mV vs. Ag/AgCl can be associated with AMI. In parallel tests, cardiac myoglobin and troponin I, the AMI biomarkers, were determined in each sample by RAMP ® immunoassay. The applicability of the electrochemical testing for AMI diagnostics was confirmed by statistical methods: generalized linear model (GLM), linear discriminant analysis (LDA) and quadratic discriminant analysis (QDA), artificial neural net (multi-layer perception, MLP), and support vector machine (SVM), all of which were created to obtain the "True-False" distribution prediction where "True" and "False" are, respectively, positive and negative decision about an illness event. © 2011 Elsevier B.V.
dc.relation.ispartofseries Biosensors and Bioelectronics
dc.subject Acute myocardial infarction
dc.subject Diagnostics
dc.subject Discriminant analysis
dc.subject Electrochemistry
dc.subject Screen-printed electrodes
dc.title Electrochemical approach for acute myocardial infarction diagnosis based on direct antibodies-free analysis of human blood plasma
dc.type Article
dc.relation.ispartofseries-issue 1
dc.relation.ispartofseries-volume 33
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 158
dc.source.id SCOPUS09565663-2012-33-1-SID84857368714


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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