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Interaction and self-organization of human mesenchymal stem cells and neuro-blastoma SH-SY5Y cells under co-culture conditions: A novel system for modeling cancer cell micro-environment

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dc.contributor.author Rizvanov A.
dc.contributor.author Yalvaç M.
dc.contributor.author Shafigullina A.
dc.contributor.author Salafutdinov I.
dc.contributor.author Blatt N.
dc.contributor.author Sahin F.
dc.contributor.author Kiyasov A.
dc.contributor.author Palotás A.
dc.date.accessioned 2018-09-18T20:11:05Z
dc.date.available 2018-09-18T20:11:05Z
dc.date.issued 2010
dc.identifier.issn 0939-6411
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/137354
dc.description.abstract The common drawback of many in vitro cell culture systems is the absence of appropriate micro-environment, which is formed by the combination of factors such as cell-cell contacts, extracellular matrix and paracrine regulation. Micro-environmental factors in a tumor tissue can influence physiological status of the cancer cells and their susceptibility to anticancer therapies. Interaction of cancer cells with their micro-environment and regional stem cells, therefore, is of particular interest. Development of in vitro systems which allow more accurate modeling of complex relations occurring in real tumor environments can increase efficiency of preclinical assays for screening anticancer drugs. The aim of this work was to study interactions between human mesenchymal stem cells (MSCs) and neuro-blastoma cancer SH-SY5Y cells under co-culture conditions on different coated surfaces to determine the effect of co-existence of cancer and stem cells on each cellular population under various stress conditions. We developed an efficient in vitro system for studying individual cancer and stem cell populations during co-culture using differential live fluorescent membrane labeling, and demonstrated self-organization of cancer and stem cells during co-culture on various coated surfaces. Our findings support the evidence that cancer and stem cell interactions play important roles in cellular behavior of cancer cells. These properties can be used in different fields of cancer research, tissue engineering and biotechnology. © 2010 Elsevier B.V.
dc.relation.ispartofseries European Journal of Pharmaceutics and Biopharmaceutics
dc.subject Cancer stem cell
dc.subject Cell fusion
dc.subject Co-culture
dc.subject Mesenchymal stem cell
dc.subject Micro-environment
dc.subject Neuro-blastoma
dc.title Interaction and self-organization of human mesenchymal stem cells and neuro-blastoma SH-SY5Y cells under co-culture conditions: A novel system for modeling cancer cell micro-environment
dc.type Article
dc.relation.ispartofseries-issue 2
dc.relation.ispartofseries-volume 76
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 253
dc.source.id SCOPUS09396411-2010-76-2-SID77957287327


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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