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dc.contributor.author | Usachev K. | |
dc.contributor.author | Efimov S. | |
dc.contributor.author | Kolosova O. | |
dc.contributor.author | Klochkova E. | |
dc.contributor.author | Aganov A. | |
dc.contributor.author | Klochkov V. | |
dc.date.accessioned | 2018-09-18T20:10:21Z | |
dc.date.available | 2018-09-18T20:10:21Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0925-2738 | |
dc.identifier.uri | https://dspace.kpfu.ru/xmlui/handle/net/137237 | |
dc.description.abstract | © 2015 Springer Science+Business Media Dordrecht. A tendency to dimerize in the presence of lipids was found for the protegrin. The dimer formation by the protegrin-1 (PG-1) is the first step for further oligomeric membrane pore formation. Generally there are two distinct model of PG-1 dimerization in either a parallel or antiparallel β-sheet. But despite the wealth of data available today, protegrin dimer structure and pore formation is still not completely understood. In order to investigate a more detailed dimerization process of PG-1 and if it will be the same for another type of protegrins, in this work we used a high-resolution NMR spectroscopy for structure determination of protegrin-3 (RGGGL-CYCRR-RFCVC-VGR) in the presence of perdeuterated DPC micelles and demonstrate that PG-3 forms an antiparallel NCCN dimer with a possible association of these dimers. This structural study complements previously published solution, solid state and computational studies of PG-1 in various environments and validate the potential of mean force simulations of PG-1 dimers and association of dimers to form octameric or decameric β-barrels. | |
dc.relation.ispartofseries | Journal of Biomolecular NMR | |
dc.subject | Antimicrobial peptide | |
dc.subject | Dimer | |
dc.subject | DPC micelle | |
dc.subject | NMR | |
dc.subject | Protegrin | |
dc.subject | Structure | |
dc.title | Antimicrobial peptide protegrin-3 adopt an antiparallel dimer in the presence of DPC micelles: A high-resolution NMR study | |
dc.type | Article | |
dc.relation.ispartofseries-issue | 1 | |
dc.relation.ispartofseries-volume | 62 | |
dc.collection | Публикации сотрудников КФУ | |
dc.relation.startpage | 71 | |
dc.source.id | SCOPUS09252738-2015-62-1-SID84939989258 |