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Characterization of the secretome of human tooth germ stem cells (hTGSCs) reveals neuro-protection by fine-tuning micro-environment

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dc.contributor.author Yalvaç M.
dc.contributor.author Yarat A.
dc.contributor.author Mercan D.
dc.contributor.author Rizvanov A.
dc.contributor.author Palotás A.
dc.contributor.author Şahin F.
dc.date.accessioned 2018-09-18T20:09:52Z
dc.date.available 2018-09-18T20:09:52Z
dc.date.issued 2013
dc.identifier.issn 0889-1591
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/137158
dc.description.abstract Bone-marrow-derived mesenchymal stem cells (MSCs) demonstrate neuro-protective effects in several disease models. By producing growth-factors, cytokines and chemokines, they promote survival of neurons in damaged brain areas. Alternative MSC sources, such as human tooth germ stem cells (hTGSCs), have been investigated for their neuro-protective properties. They ameliorate effects of neuro-toxic agents by paracrine mechanisms, however these secreted bio-active molecules are not yet characterized. Therefore, the current study aimed to provide a detailed analysis of the secretome of hTGSCs. Brain cells were exposed to various toxic materials, including Alzheimer's β-amyloid peptide (β-AP) and 6-hydroxydopamine (6-OHDA). When co-cultured with hTGSCs, the activity of a number of anti-oxidant enzymes (catalase, glutathione-s-transferase, glutathione-peroxidase, superoxide-dismutase) was increased and neuronal death/apoptosis was subsequently reduced. The composition of the secreted bio-active materials is influenced by various pre-existing factors such as oxygen and glucose deprivation and the age of cells (passage number). This report reveals for the first time that the neuro-protective secretome of hTGSCs and the micro-environment of cells have a mutual and dynamic impact on one another. © 2013 Elsevier Inc.
dc.relation.ispartofseries Brain, Behavior, and Immunity
dc.subject Bio-active molecules
dc.subject Cytokine
dc.subject Human tooth germ stem cells (hTGSCs)
dc.subject Neuro-protection
dc.subject Secretome
dc.subject Toxicity
dc.title Characterization of the secretome of human tooth germ stem cells (hTGSCs) reveals neuro-protection by fine-tuning micro-environment
dc.type Article
dc.relation.ispartofseries-volume 32
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 122
dc.source.id SCOPUS08891591-2013-32-SID84891373337


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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