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dc.contributor.author | Yalvaç M. | |
dc.contributor.author | Yarat A. | |
dc.contributor.author | Mercan D. | |
dc.contributor.author | Rizvanov A. | |
dc.contributor.author | Palotás A. | |
dc.contributor.author | Şahin F. | |
dc.date.accessioned | 2018-09-18T20:09:52Z | |
dc.date.available | 2018-09-18T20:09:52Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0889-1591 | |
dc.identifier.uri | https://dspace.kpfu.ru/xmlui/handle/net/137158 | |
dc.description.abstract | Bone-marrow-derived mesenchymal stem cells (MSCs) demonstrate neuro-protective effects in several disease models. By producing growth-factors, cytokines and chemokines, they promote survival of neurons in damaged brain areas. Alternative MSC sources, such as human tooth germ stem cells (hTGSCs), have been investigated for their neuro-protective properties. They ameliorate effects of neuro-toxic agents by paracrine mechanisms, however these secreted bio-active molecules are not yet characterized. Therefore, the current study aimed to provide a detailed analysis of the secretome of hTGSCs. Brain cells were exposed to various toxic materials, including Alzheimer's β-amyloid peptide (β-AP) and 6-hydroxydopamine (6-OHDA). When co-cultured with hTGSCs, the activity of a number of anti-oxidant enzymes (catalase, glutathione-s-transferase, glutathione-peroxidase, superoxide-dismutase) was increased and neuronal death/apoptosis was subsequently reduced. The composition of the secreted bio-active materials is influenced by various pre-existing factors such as oxygen and glucose deprivation and the age of cells (passage number). This report reveals for the first time that the neuro-protective secretome of hTGSCs and the micro-environment of cells have a mutual and dynamic impact on one another. © 2013 Elsevier Inc. | |
dc.relation.ispartofseries | Brain, Behavior, and Immunity | |
dc.subject | Bio-active molecules | |
dc.subject | Cytokine | |
dc.subject | Human tooth germ stem cells (hTGSCs) | |
dc.subject | Neuro-protection | |
dc.subject | Secretome | |
dc.subject | Toxicity | |
dc.title | Characterization of the secretome of human tooth germ stem cells (hTGSCs) reveals neuro-protection by fine-tuning micro-environment | |
dc.type | Article | |
dc.relation.ispartofseries-volume | 32 | |
dc.collection | Публикации сотрудников КФУ | |
dc.relation.startpage | 122 | |
dc.source.id | SCOPUS08891591-2013-32-SID84891373337 |