Электронный архив

Efficiency of new pyrimidine derivativs influence on physical working capacity of rats in the test 'swimming to failure'

Показать сокращенную информацию

dc.contributor.author Zobov V.
dc.contributor.author Nazarov N.
dc.contributor.author Vyshtakalyuk A.
dc.contributor.author Galyametdinova I.
dc.contributor.author Semenov V.
dc.contributor.author Reznik V.
dc.date.accessioned 2018-09-18T20:08:15Z
dc.date.available 2018-09-18T20:08:15Z
dc.date.issued 2015
dc.identifier.issn 0300-7839
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/136871
dc.description.abstract © Northern State Medical University. There have been studied effects of xymedon and six new pyrimidine derivatives, that are close and distant analogs of xymedon, on rats' working capacity in the test "swimming to failure". It has been shown that a single administration of the studied compounds did not have a statistically significant effect in the test. In the conditions of multiple intraperitoneal administration of the studied pyrimidine derivatives, the compound L-ascorbate, 1-(2-hydroxyethyl)-4.6-dimethyl-1.2-dihydropyrimidine-2-one had the lowest toxicity and the most pronounced actoprotective effect. Introduction in the dose of 20 mg/kg caused a statistically significant increase 440 % in the duration of swimming of rats on the 14th day of the experiment compared with the control group. Multiple administration of the compound in the conditions of physical load did not affect leucopoiesis, but stimulates erythropoiesis resulting in an increase in the number of erythrocytes and a hemoglobin level. The substance introduction under mixed exhausting loads prevented such changes of blood biochemical parameters as reduction of glucose, increased of urea and lactic acid levels, what indicates improvement in the animals' tolerability of loads and an anti-catabolic effect of the compound. Absence of hepato- and cardiotoxic effects of the substance has been shown.
dc.relation.ispartofseries Human Ecology
dc.subject Physical working capacity
dc.subject Pyrimidine derivatives
dc.subject Stimulation efficiency
dc.subject Swimming to failure
dc.subject Xymedon
dc.title Efficiency of new pyrimidine derivativs influence on physical working capacity of rats in the test 'swimming to failure'
dc.type Article
dc.relation.ispartofseries-issue 1
dc.relation.ispartofseries-volume 2015
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 28
dc.source.id SCOPUS03007839-2015-2015-1-SID84953853965


Файлы в этом документе

Данный элемент включен в следующие коллекции

  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

Показать сокращенную информацию

Поиск в электронном архиве


Расширенный поиск

Просмотр

Моя учетная запись

Статистика